7VYX
| Crystal structure of the selenomethionine(SeMet)-derived Cas12c1 (D969A) ternary complex | Descriptor: | Non-target DNA strand, Selenomethionine (SeMet)-labeled Cas12c1 D969A mutant, Target DNA strand, ... | Authors: | Zhang, B, Lin, J.Y, Perculija, V, OuYang, S.Y. | Deposit date: | 2021-11-15 | Release date: | 2022-11-02 | Last modified: | 2023-06-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insights into target DNA recognition and cleavage by the CRISPR-Cas12c1 system Nucleic Acids Res., 50, 2022
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7XMV
| E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A(AMP/ADP) filament bound with ADP, AMP and R5P | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ... | Authors: | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | Deposit date: | 2022-04-27 | Release date: | 2022-06-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XN3
| E.coli phosphoribosylpyrophosphate (PRPP) synthetase type B filament bound with Pi | Descriptor: | PHOSPHATE ION, Ribose-phosphate pyrophosphokinase | Authors: | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | Deposit date: | 2022-04-27 | Release date: | 2022-06-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7XMU
| E.coli phosphoribosylpyrophosphate (PRPP) synthetase type A filament bound with ADP, Pi and R5P | Descriptor: | 5-O-phosphono-alpha-D-ribofuranose, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Hu, H.H, Lu, G.M, Chang, C.C, Liu, J.L. | Deposit date: | 2022-04-26 | Release date: | 2022-06-29 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.3 Å) | Cite: | Filamentation modulates allosteric regulation of PRPS. Elife, 11, 2022
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7X6T
| Discovery of Selective BRD4 BD1 Inhibitor Based on [1,2,4] triazolo [4,3-b] pyridazine Scaffold | Descriptor: | (2~{R})-2-[[3-methyl-6-(2-phenoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]amino]propanamide, Isoform C of Bromodomain-containing protein 4 | Authors: | Cao, D, Xiong, B. | Deposit date: | 2022-03-08 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | Discovery of Selective BRD4 BD1 Inhibitor Based on [1,2,4] triazolo [4,3-b] pyridazine Scaffold To Be Published
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7YG2
| Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DBLMSP2, ... | Authors: | Shen, H, Ji, C, Xiao, J. | Deposit date: | 2022-07-09 | Release date: | 2023-03-29 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.32 Å) | Cite: | Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nat Commun, 14, 2023
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7Y0J
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7Y0H
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7YHN
| ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | Deposit date: | 2022-07-14 | Release date: | 2023-07-26 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J.Med.Chem., 65, 2022
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7Y09
| Cryo-EM structure of human IgM-Fc in complex with the J chain and the DBL domain of DBLMSP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin J chain, ... | Authors: | Shen, H, Ji, C, Xiao, J. | Deposit date: | 2022-06-03 | Release date: | 2023-03-29 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Plasmodium falciparum has evolved multiple mechanisms to hijack human immunoglobulin M. Nat Commun, 14, 2023
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7WMK
| PQQ-dependent alcohol dehydrogenase complexed with PQQ | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, CALCIUM ION, ... | Authors: | Chen, M, Yang, H, Lv, F. | Deposit date: | 2022-01-15 | Release date: | 2022-09-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Structure-Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification. J.Agric.Food Chem., 70, 2022
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7WMD
| PQQ-dependent alcohol dehydrogenase detoxifying DON | Descriptor: | CALCIUM ION, PQQ-dependent alcohol dehydrogenase | Authors: | Chen, M, Yang, H, Lv, F. | Deposit date: | 2022-01-14 | Release date: | 2022-09-07 | Last modified: | 2024-10-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure-Function Analysis of a Quinone-Dependent Dehydrogenase Capable of Deoxynivalenol Detoxification. J.Agric.Food Chem., 70, 2022
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8JVB
| Cryo-EM structure of the Type II secretion system protein from Acidithiobacillus caldus | Descriptor: | Type II and III secretion system protein | Authors: | Liu, R.H, Zhang, K, Feng, Q.S, Dai, X, Fu, Y, Li, Y. | Deposit date: | 2023-06-28 | Release date: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (2.39 Å) | Cite: | Cryo-EM structure of the Type II secretion system protein from Acidithiobacillus caldus To Be Published
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6AOG
| Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine (pyrimethamine) | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-CHLORO-PHENYL)-6-ETHYL-PYRIMIDINE-2,4-DIAMINE, ... | Authors: | Thomas, S.B, Li, Y, Chen, Z, Lu, H. | Deposit date: | 2017-08-16 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published
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6AOI
| Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine (TRC-2528) | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-(4-phenylpiperazin-1-yl)-6-propylpyrimidine-2,4-diamine, ... | Authors: | Thomas, S.B, Li, Y, Chen, Z, Lu, H. | Deposit date: | 2017-08-16 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.97 Å) | Cite: | Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published
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5ZKA
| Crystal structure of N-acetylneuraminate lyase from Fusobacterium nucleatum complexed with Pyruvate | Descriptor: | 1,2-ETHANEDIOL, N-acetylneuraminate lyase, TRIETHYLENE GLYCOL | Authors: | Kumar, J.P, Rao, H, Nayak, V, Ramaswamy, S. | Deposit date: | 2018-03-23 | Release date: | 2018-12-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum Acta Crystallogr F Struct Biol Commun, 74, 2018
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6AOH
| Crystal structure of Toxoplasma gondii TS-DHFR complexed with NADPH, dUMP, PDDF, and 5-(4-(3-(2-methoxypyrimidin-5-yl)phenyl)piperazin-1-yl)pyrimidine-2,4-diamine (TRC-2533) | Descriptor: | 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 5-{4-[3-(2-methoxypyrimidin-5-yl)phenyl]piperazin-1-yl}pyrimidine-2,4-diamine, ... | Authors: | Thomas, S.B, Li, Y, Chen, Z, Lu, H. | Deposit date: | 2017-08-16 | Release date: | 2018-08-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Identification of selective, brain penetrant Toxoplasma gondii dihydrofolate reductase inhibitors for the treatment of toxoplasmosis To Be Published
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6LIM
| BRD4-BD1 bound with compound 40 | Descriptor: | (3~{R})-6-[(4-isoquinolin-4-ylpyrimidin-2-yl)amino]-1,3-dimethyl-4-propan-2-yl-3~{H}-quinoxalin-2-one, Bromodomain-containing protein 4 | Authors: | Xiong, B, Cao, D, Li, Y. | Deposit date: | 2019-12-12 | Release date: | 2020-12-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.75909507 Å) | Cite: | BRD4-BD1 bound with compound 40 To Be Published
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