7X6T

Discovery of Selective BRD4 BD1 Inhibitor Based on [1,2,4] triazolo [4,3-b] pyridazine Scaffold

Summary for 7X6T

• Entry DOI: 10.2210/pdb7x6t/pdb
• Descriptor: Isoform C of Bromodomain-containing protein 4, (2~{R})-2-[[3-methyl-6-(2-phenoxyphenyl)-[1,2,4]triazolo[4,3-b]pyridazin-8-yl]amino]propanamide (3 entities in total)
• Functional Keywords: bromodomain, dna binding protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 15128.47

Authors

Cao, D.,Xiong, B. (deposition date: 2022-03-08, release date: 2023-03-22, Last modification date: 2023-11-29)

• Primary citation: Hanyue, Z.,Cao, D.,Li, Y.,Du, Z.,Xiong, B.; Discovery of Selective BRD4 BD1 Inhibitor Based on [1,2,4] triazolo [4,3-b] pyridazine Scaffold; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.44 Å)