1BF8
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![BU of 1bf8 by Molmil](/molmil-images/mine/1bf8) | PERIPLASMIC CHAPERONE FIMC, NMR, 20 STRUCTURES | Descriptor: | CHAPERONE PROTEIN FIMC | Authors: | Pellecchia, M, Guntert, P, Glockshuber, R, Wuthrich, K. | Deposit date: | 1998-05-28 | Release date: | 1998-11-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR solution structure of the periplasmic chaperone FimC. Nat.Struct.Biol., 5, 1998
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1DG4
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![BU of 1dg4 by Molmil](/molmil-images/mine/1dg4) | NMR STRUCTURE OF THE SUBSTRATE BINDING DOMAIN OF DNAK IN THE APO FORM | Descriptor: | DNAK | Authors: | Pellecchia, M, Montgomery, D.L, Stevens, S.Y, Van der Kooi, C.W, Feng, H, Gierasch, L.M, Zuiderweg, E.R.P. | Deposit date: | 1999-11-23 | Release date: | 1999-12-08 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural insights into substrate binding by the molecular chaperone DnaK. Nat.Struct.Biol., 7, 2000
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1XBL
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![BU of 1xbl by Molmil](/molmil-images/mine/1xbl) | NMR STRUCTURE OF THE J-DOMAIN (RESIDUES 2-76) IN THE ESCHERICHIA COLI N-TERMINAL FRAGMENT (RESIDUES 2-108) OF THE MOLECULAR CHAPERONE DNAJ, 20 STRUCTURES | Descriptor: | DNAJ | Authors: | Pellecchia, M, Szyperski, T, Wall, D, Georgopoulos, C, Wuthrich, K. | Deposit date: | 1996-10-07 | Release date: | 1997-01-11 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone. J.Mol.Biol., 260, 1996
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6VBX
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![BU of 6vbx by Molmil](/molmil-images/mine/6vbx) | Crystal structure of Mcl-1 in complex with 138E12 peptide, Lys-covalent antagonist | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Synthetic peptide | Authors: | Pellecchia, M, Perry, J.J, Kenjic, N, Assar, Z. | Deposit date: | 2019-12-19 | Release date: | 2020-12-30 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1. J.Med.Chem., 64, 2021
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2GAQ
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8GH7
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![BU of 8gh7 by Molmil](/molmil-images/mine/8gh7) | 142D6 bound to BIR3-XIAP | Descriptor: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, BIR3 inhibitor MAA-CHG-PRO-ZHW, E3 ubiquitin-protein ligase XIAP, ... | Authors: | Garza-Granados, A, McGuire, J, Baggio, C, Pellecchia, M, Pegan, S.D. | Deposit date: | 2023-03-09 | Release date: | 2023-07-05 | Last modified: | 2023-07-12 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J.Med.Chem., 66, 2023
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8VJP
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![BU of 8vjp by Molmil](/molmil-images/mine/8vjp) | Histidine-covalent stapled alpha-helical peptide (155H1) targeting hMcl-1 | Descriptor: | (4Z)-oct-4-en-1-ol, (S~1~R)-3-carbamoyl-4-methoxybenzene-1-sulfinic acid, Histidine-covalent stapled alpha-helical peptide, ... | Authors: | Muzzarelli, K.M, Assar, Z, Alboreggia, G, Pellecchia, M. | Deposit date: | 2024-01-07 | Release date: | 2024-05-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.13 Å) | Cite: | Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1. J.Med.Chem., 67, 2024
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2FNB
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![BU of 2fnb by Molmil](/molmil-images/mine/2fnb) | NMR STRUCTURE OF THE FIBRONECTIN ED-B DOMAIN, NMR, 20 STRUCTURES | Descriptor: | PROTEIN (FIBRONECTIN) | Authors: | Fattorusso, R, Pellecchia, M, Viti, F, Neri, P, Neri, D, Wuthrich, K. | Deposit date: | 1998-12-16 | Release date: | 1998-12-23 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | NMR structure of the human oncofoetal fibronectin ED-B domain, a specific marker for angiogenesis. Structure Fold.Des., 7, 1999
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6RJP
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![BU of 6rjp by Molmil](/molmil-images/mine/6rjp) | Bfl-1 in complex with alpha helical peptide | Descriptor: | Bcl-2-like protein 11, Bcl-2-related protein A1 | Authors: | Baggio, C, Gambini, L, Udompholkul, P, Salem, A.F, Hakansson, M, Jossart, J, Perry, J, Pellecchia, M. | Deposit date: | 2019-04-29 | Release date: | 2019-10-30 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | N-locking stabilization of covalent helical peptides: Application to Bfl-1 antagonists. Chem.Biol.Drug Des., 95, 2020
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7OFV
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![BU of 7ofv by Molmil](/molmil-images/mine/7ofv) | NMR-guided design of potent and selective EphA4 agonistic ligands | Descriptor: | ACETATE ION, EphA4 agonist ligand, Ephrin type-A receptor 4 | Authors: | Ganichkin, O.M, Craig, T.K, Baggio, C, Pellecchia, M. | Deposit date: | 2021-05-05 | Release date: | 2021-08-11 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | NMR-Guided Design of Potent and Selective EphA4 Agonistic Ligands. J.Med.Chem., 64, 2021
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1Q5L
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![BU of 1q5l by Molmil](/molmil-images/mine/1q5l) | NMR structure of the substrate binding domain of DnaK bound to the peptide NRLLLTG | Descriptor: | Chaperone protein dnaK, peptide NRLLLTG | Authors: | Stevens, S.Y, Cai, S, Pellecchia, M, Zuiderweg, E.R. | Deposit date: | 2003-08-08 | Release date: | 2003-11-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the bacterial HSP70 chaperone protein domain DnaK(393-507) in complex with the peptide NRLLLTG. Protein Sci., 12, 2003
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2LWK
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![BU of 2lwk by Molmil](/molmil-images/mine/2lwk) | Solution structure of small molecule-influenza RNA complex | Descriptor: | 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine, RNA (32-MER) | Authors: | Lee, M.-K, Varani, G, Choi, B.-S, Pellecchia, M, Seattle Structural Genomics Center for Infectious Disease (SSGCID) | Deposit date: | 2012-08-01 | Release date: | 2012-08-29 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | A novel small-molecule binds to the influenza A virus RNA promoter and inhibits viral replication. Chem.Commun.(Camb.), 50, 2014
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2KG5
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![BU of 2kg5 by Molmil](/molmil-images/mine/2kg5) | NMR Solution structure of ARAP3-SAM | Descriptor: | Arf-GAP, Rho-GAP domain, ANK repeat and PH domain-containing protein 3 | Authors: | Leone, M, Pellecchia, M. | Deposit date: | 2009-03-05 | Release date: | 2009-11-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The Sam domain of the lipid phosphatase Ship2 adopts a common model to interact with Arap3-Sam and EphA2-Sam. Bmc Struct.Biol., 9, 2009
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2K4P
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![BU of 2k4p by Molmil](/molmil-images/mine/2k4p) | Solution Structure of Ship2-Sam | Descriptor: | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2 | Authors: | Leone, M, Pellecchia, M. | Deposit date: | 2008-06-16 | Release date: | 2008-11-25 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR Studies of a Heterotypic Sam-Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor. Biochemistry, 47, 2008
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2GJY
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2A26
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![BU of 2a26 by Molmil](/molmil-images/mine/2a26) | Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein | Descriptor: | 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, Calcyclin-binding protein, SULFATE ION | Authors: | Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S. | Deposit date: | 2005-06-21 | Release date: | 2005-08-09 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex J.Biol.Chem., 280, 2005
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2A25
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![BU of 2a25 by Molmil](/molmil-images/mine/2a25) | Crystal structure of Siah1 SBD bound to the peptide EKPAAVVAPITTG from SIP | Descriptor: | Calcyclin-binding protein peptide, Ubiquitin ligase SIAH1, ZINC ION | Authors: | Santelli, E, Leone, M, Li, C, Fukushima, T, Preece, N.E, Olson, A.J, Ely, K.R, Reed, J.C, Pellecchia, M, Liddington, R.C, Matsuzawa, S. | Deposit date: | 2005-06-21 | Release date: | 2005-08-09 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Analysis of Siah1-Siah-interacting Protein Interactions and Insights into the Assembly of an E3 Ligase Multiprotein Complex J.Biol.Chem., 280, 2005
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2LK0
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2LK1
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4I7C
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![BU of 4i7c by Molmil](/molmil-images/mine/4i7c) | Siah1 mutant bound to synthetic peptide (ACE)KLRPV(23P)MVRPWVR | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ... | Authors: | Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-14 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-based design of covalent siah inhibitors. Chem.Biol., 20, 2013
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4I7D
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![BU of 4i7d by Molmil](/molmil-images/mine/4i7d) | Siah1 bound to synthetic peptide (ACE)KLRPVAMVRP(PRK)VR | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ... | Authors: | Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-based design of covalent siah inhibitors. Chem.Biol., 20, 2013
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4I7B
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![BU of 4i7b by Molmil](/molmil-images/mine/4i7b) | Siah1 bound to synthetic peptide (ACE)KLRPV(ABA)MVRPTVR | Descriptor: | E3 ubiquitin-protein ligase SIAH1, Protein phyllopod, ZINC ION | Authors: | Santelli, E, Stebbins, J.L, Feng, Y, De, S.K, Purves, A, Motamedchaboki, K, Wu, B, Ronai, Z.A, Liddington, R.C, Pellecchia, M. | Deposit date: | 2012-11-30 | Release date: | 2013-08-14 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure-based design of covalent siah inhibitors. Chem.Biol., 20, 2013
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3F81
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![BU of 3f81 by Molmil](/molmil-images/mine/3f81) | Interaction of VHR with SA3 | Descriptor: | 2-[(5~{E})-5-[[3-[4-(2-fluoranylphenoxy)phenyl]-1-phenyl-pyrazol-4-yl]methylidene]-4-oxidanylidene-2-sulfanylidene-1,3-thiazolidin-3-yl]ethanesulfonic acid, Dual specificity protein phosphatase 3 | Authors: | Wu, S, Mutelin, T, Tautz, L. | Deposit date: | 2008-11-11 | Release date: | 2009-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J.Med.Chem., 52, 2009
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6B9L
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![BU of 6b9l by Molmil](/molmil-images/mine/6b9l) | Crystal structure of EphA2 with peptide 135E2 | Descriptor: | Ephrin type-A receptor 2, HIS TAG CLEAVED OFF, peptide 135E2, ... | Authors: | Song, J, Tan, X. | Deposit date: | 2017-10-10 | Release date: | 2018-10-17 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell. ACS Chem. Biol., 13, 2018
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2LMR
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![BU of 2lmr by Molmil](/molmil-images/mine/2lmr) | Solution structure of the first sam domain of odin | Descriptor: | Ankyrin repeat and SAM domain-containing protein 1A | Authors: | Leone, M, Mercurio, F. | Deposit date: | 2011-12-12 | Release date: | 2012-03-14 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure of the First Sam Domain of Odin and Binding Studies with the EphA2 Receptor. Biochemistry, 51, 2012
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