1BHF
 
 | | P56LCK SH2 DOMAIN INHIBITOR COMPLEX | | Descriptor: | INHIBITOR ACE-IPA-GLU-GLU-ILE, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK | | Authors: | Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. | | Deposit date: | 1998-06-08 | | Release date: | 1998-10-21 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
|
|
1BHH
 | | FREE P56LCK SH2 DOMAIN | | Descriptor: | P56 LCK TYROSINE KINASE SH2 DOMAIN, T-LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE P56LCK | | Authors: | Tong, L, Warren, T.C, Lukas, S, Schembri-King, J, Betageri, R, Proudfoot, J.R, Jakes, S. | | Deposit date: | 1998-06-08 | | Release date: | 1998-10-21 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding.
J.Biol.Chem., 273, 1998
|
|
2KFB
 | | The structure of the cataract causing P23T mutant of human gamma-D crystallin | | Descriptor: | Gamma-crystallin D | | Authors: | Jung, J, Byeon, I.L, Wang, Y, King, J, Gronenborn, A.M. | | Deposit date: | 2009-02-12 | | Release date: | 2009-07-28 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The structure of the cataract-causing P23T mutant of human gammaD-crystallin exhibits distinctive local conformational and dynamic changes.
Biochemistry, 48, 2009
|
|
3CQV
 | | Crystal structure of Reverb beta in complex with heme | | Descriptor: | Nuclear receptor subfamily 1 group D member 2, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Xu, X, Dong, A, Pardee, K.I, Reinking, J, Krause, H, Schuetz, A, Zhang, R, Cui, H, Edwards, A, Arrowsmith, C.H, Weigelt, J, Bountra, C, Savchenko, A, Botchkarev, A, Structural Genomics Consortium (SGC) | | Deposit date: | 2008-04-03 | | Release date: | 2008-08-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The structural basis of gas-responsive transcription by the human nuclear hormone receptor REV-ERBbeta.
Plos Biol., 7, 2009
|
|
2DFK
 | | Crystal structure of the CDC42-Collybistin II complex | | Descriptor: | GLYCEROL, SULFATE ION, cell division cycle 42 isoform 1, ... | | Authors: | Xiang, S, Kim, E.Y, Connelly, J.J, Nassar, N, Kirsch, J, Winking, J, Schwarz, G, Schindelin, H. | | Deposit date: | 2006-03-02 | | Release date: | 2006-05-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The Crystal Structure of Cdc42 in Complex with Collybistin II, a Gephyrin-interacting Guanine Nucleotide Exchange Factor.
J.Mol.Biol., 359, 2006
|
|
1O8N
 | | The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G | | Descriptor: | MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN | | Authors: | Kuper, J, Winking, J, Hecht, H.J, Schwarz, G, Mendel, R.R. | | Deposit date: | 2002-11-28 | | Release date: | 2003-02-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Active Site of the Molybdenum Cofactor Biosynthetic Protein Domain Cnx1G
Arch.Biochem.Biophys., 411, 2003
|
|
1O8Q
 | | The active site of the molybdenum cofactor biosenthetic protein domain Cnx1G | | Descriptor: | MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN | | Authors: | Kuper, J, Winking, J, Hecht, H.J, Schwarz, G, Mendel, R.R. | | Deposit date: | 2002-11-28 | | Release date: | 2003-02-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The Active Site of the Molybdenum Cofactor Biosynthetic Protein Domain Cnx1G
Arch.Biochem.Biophys., 411, 2003
|
|
1O8O
 | | The active site of the molybdenum cofactor biosynthetic protein domain Cnx1G | | Descriptor: | MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN | | Authors: | Kuper, J, Winking, J, Hecht, H.J, Schwarz, G, Mendel, R.R. | | Deposit date: | 2002-11-28 | | Release date: | 2003-12-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The Active Site of the Molybdenum Cofactor Biosynthetic Protein Domain Cnx1G
Arch.Biochem.Biophys., 411, 2003
|
|
6ZLE
 | |
4BML
 | | C-alpha backbone trace of major capsid protein gp39 found in marine virus Syn5. | | Descriptor: | MAJOR CAPSID PROTEIN | | Authors: | Gipson, P, Baker, M.L, Raytcheva, D, Haase-Pettingell, C, Piret, J, King, J, Chiu, W. | | Deposit date: | 2013-05-09 | | Release date: | 2014-05-21 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.7 Å) | | Cite: | Protruding Knob-Like Proteins Violate Local Symmetries in an Icosahedral Marine Virus.
Nat.Commun., 5, 2014
|
|
8H7A
 | | Crystal structure of the dimer form KAT6A WH domain with its bound double stranded DNA | | Descriptor: | DNA (5'-D(*GP*GP*TP*CP*CP*GP*AP*CP*GP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*CP*GP*TP*CP*GP*GP*AP*CP*C)-3'), Histone acetyltransferase KAT6A, ... | | Authors: | Wang, Z, Cao, Y. | | Deposit date: | 2022-10-19 | | Release date: | 2023-01-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.
Nucleic Acids Res., 51, 2023
|
|
8SMT
 | | Crystal structure of antibody WRAIR-2134 in complex with SARS-CoV-2 receptor binding domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, WRAIR-2134 Fab heavy chain, ... | | Authors: | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | | Deposit date: | 2023-04-26 | | Release date: | 2023-06-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.16 Å) | | Cite: | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.
Structure, 32, 2024
|
|
8SGU
 | | Crystal structure of the SARS-CoV-2 receptor binding domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | Authors: | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | | Deposit date: | 2023-04-13 | | Release date: | 2023-12-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.
Structure, 32, 2024
|
|
8SMI
 | | Crystal structure of antibody WRAIR-2123 in complex with SARS-CoV-2 receptor binding domain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, WRAIR-2123 Fab heavy chain, ... | | Authors: | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | | Deposit date: | 2023-04-26 | | Release date: | 2023-12-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.
Structure, 32, 2024
|
|
7NM5
 | | Solution structure of MLKL executioner domain in complex with a fragment | | Descriptor: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2021-02-23 | | Release date: | 2021-09-22 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
|
|
7NM2
 | | Solution structure of MLKL executioner domain in complex with a fragment | | Descriptor: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2021-02-23 | | Release date: | 2021-09-22 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
|
|
7NM4
 | | Solution structure of MLKL executioner domain in complex with a fragment | | Descriptor: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2021-02-23 | | Release date: | 2021-09-22 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
|
|
8FAH
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with SARS-CoV-2 reactive human antibody CR3022 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab heavy chain, CR3022 Fab light chain, ... | | Authors: | Sankhala, R.S, Jensen, J.L, Joyce, M.G. | | Deposit date: | 2022-11-26 | | Release date: | 2023-12-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (4.22 Å) | | Cite: | Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain.
Structure, 32, 2024
|
|
7S83
 | | Crystal structure of SARS CoV-2 Spike Receptor Binding Domain in complex with shark neutralizing VNARs ShAb01 and ShAb02 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ShAb01 VNAR, ... | | Authors: | Chen, W.-H, Hajduczki, A, Dooley, H.M, Joyce, M.G. | | Deposit date: | 2021-09-17 | | Release date: | 2022-11-23 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity.
Nat Commun, 14, 2023
|
|
7U8E
 | |
1I5I
 | | THE C18S MUTANT OF BOVINE (GAMMA-B)-CRYSTALLIN | | Descriptor: | (GAMMA-B) CRYSTALLIN | | Authors: | Zarutskie, J.A, Asherie, N, Pande, J, Pande, A, Lomakin, J, Lomakin, A, Ogun, O, Stern, L.J, King, J.A, Benedek, G.B. | | Deposit date: | 2001-02-27 | | Release date: | 2001-03-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Enhanced crystallization of the Cys18 to Ser mutant of bovine gammaB crystallin.
J.Mol.Biol., 314, 2001
|
|
6ZPR
 | | Solution structure of MLKL executioner domain in complex with a covalent inhibitor | | Descriptor: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2020-07-09 | | Release date: | 2020-12-16 | | Last modified: | 2021-01-06 | | Method: | SOLUTION NMR | | Cite: | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6ZVO
 | | Crystal structure of unliganded MLKL executioner domain | | Descriptor: | BROMIDE ION, CHLORIDE ION, Mixed lineage kinase domain-like protein | | Authors: | Fiegen, D, Bauer, M, Nar, H. | | Deposit date: | 2020-07-27 | | Release date: | 2020-12-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.371 Å) | | Cite: | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6ZZ1
 | | Crystal structure of MLKL executioner domain in complex with a covalent inhibitor | | Descriptor: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein | | Authors: | Fiegen, D, Bauer, M, Nar, H. | | Deposit date: | 2020-08-03 | | Release date: | 2020-12-23 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
7Y43
 | | Crystal structure of the KAT6A WH domain and its bound double stranded DNA | | Descriptor: | DNA (5'-D(*GP*GP*AP*GP*TP*GP*CP*GP*CP*AP*CP*TP*CP*C)-3'), Histone acetyltransferase KAT6A, MAGNESIUM ION | | Authors: | Wang, Z, Jia, Y. | | Deposit date: | 2022-06-13 | | Release date: | 2023-01-18 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.
Nucleic Acids Res., 51, 2023
|
|
