5CMD
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5D65
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![BU of 5d65 by Molmil](/molmil-images/mine/5d65) | X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) WITH HEPARIN COMPLEX | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, C-C motif chemokine 3, CHLORIDE ION, ... | Authors: | Liang, W.G, Hwang, D.Y, Zulueta, M.M, Hung, S.C, Tang, W. | Deposit date: | 2015-08-11 | Release date: | 2016-04-20 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Proc.Natl.Acad.Sci.USA, 113, 2016
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5DNF
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![BU of 5dnf by Molmil](/molmil-images/mine/5dnf) | Crystal structure of CC chemokine 5 (CCL5) oligomer in complex with heparin | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, C-C motif chemokine 5, ... | Authors: | Liang, W.G, Tang, W. | Deposit date: | 2015-09-10 | Release date: | 2016-04-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.549 Å) | Cite: | Structural basis for oligomerization and glycosaminoglycan binding of CCL5 and CCL3. Proc.Natl.Acad.Sci.USA, 113, 2016
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3OFI
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![BU of 3ofi by Molmil](/molmil-images/mine/3ofi) | Crystal structure of human insulin-degrading enzyme in complex with ubiquitin | Descriptor: | 1,4-DIETHYLENE DIOXIDE, Insulin-degrading enzyme, Ubiquitin, ... | Authors: | Kalas, V, Ralat, L.A, Tang, W.-J. | Deposit date: | 2010-08-15 | Release date: | 2010-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Ubiquitin is a novel substrate for human insulin-degrading enzyme. J.Mol.Biol., 406, 2011
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4NXO
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![BU of 4nxo by Molmil](/molmil-images/mine/4nxo) | Crystal Structure of Insulin Degrading Enzyme in complex with BDM44768 | Descriptor: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Liang, W.G, Deprez, R, Deprez, B, Tang, W. | Deposit date: | 2013-12-09 | Release date: | 2015-10-07 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.73 Å) | Cite: | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
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4MHE
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![BU of 4mhe by Molmil](/molmil-images/mine/4mhe) | Crystal structure of CC-chemokine 18 | Descriptor: | ACETATE ION, C-C motif chemokine 18 | Authors: | Liang, W.G, Tang, W.-J. | Deposit date: | 2013-08-29 | Release date: | 2014-09-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of human CCL18, CCL3, and CCL4 reveal molecular determinants for quaternary structures and sensitivity to insulin-degrading enzyme. J.Mol.Biol., 427, 2015
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4IFH
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![BU of 4ifh by Molmil](/molmil-images/mine/4ifh) | Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM44619 | Descriptor: | Insulin-degrading enzyme, N-({1-[(2R)-4-(hydroxyamino)-1-(naphthalen-2-yl)-4-oxobutan-2-yl]-1H-1,2,3-triazol-4-yl}methyl)-4-methylbenzamide, ZINC ION | Authors: | Liang, W.G, Guo, Q, Deprez, R, Deprez, B, Tang, W. | Deposit date: | 2012-12-14 | Release date: | 2013-12-18 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3.286 Å) | Cite: | Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice. Nat Commun, 6, 2015
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4Z6G
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![BU of 4z6g by Molmil](/molmil-images/mine/4z6g) | Structure of NT domain | Descriptor: | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, PHOSPHATE ION | Authors: | Yang, F, Zhang, Y. | Deposit date: | 2015-04-05 | Release date: | 2016-04-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.654 Å) | Cite: | In vivo epidermal migration requires focal adhesion targeting of ACF7. Nat Commun, 7, 2016
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6AZ2
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![BU of 6az2 by Molmil](/molmil-images/mine/6az2) | Crystal structure of Asf1-Fab 12E complex | Descriptor: | Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1 | Authors: | Bailey, L.J, Kossiakoff, A.A. | Deposit date: | 2017-09-09 | Release date: | 2018-01-10 | Last modified: | 2018-02-14 | Method: | X-RAY DIFFRACTION (2.477 Å) | Cite: | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J. Mol. Biol., 430, 2018
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6AYZ
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![BU of 6ayz by Molmil](/molmil-images/mine/6ayz) | Crystal structure of Asf1-Fab 12E complex | Descriptor: | Fab Heavy Chain, Fab Light Chain, Histone chaperone ASF1 | Authors: | Bailey, L.J, Kossiakoff, A.A. | Deposit date: | 2017-09-08 | Release date: | 2018-01-17 | Last modified: | 2020-01-01 | Method: | X-RAY DIFFRACTION (2.096 Å) | Cite: | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. J. Mol. Biol., 430, 2018
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4LTE
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![BU of 4lte by Molmil](/molmil-images/mine/4lte) | Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor | Descriptor: | 2,6-DIAMINO-HEXANOIC ACID AMIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FUMARIC ACID, ... | Authors: | Foda, Z.H, Seeliger, M.A, Saghatelian, A, Liu, D.R. | Deposit date: | 2013-07-23 | Release date: | 2014-05-21 | Last modified: | 2024-04-24 | Method: | X-RAY DIFFRACTION (2.705 Å) | Cite: | Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 511, 2014
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6MQ3
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![BU of 6mq3 by Molmil](/molmil-images/mine/6mq3) | Structure of Cysteine-free Human Insulin-Degrading Enzyme in complex with Substrate-selective Macrocycle Inhibitor 63 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Insulin-degrading enzyme, {(8R,9S,10S)-9-(2',3'-dimethyl[1,1'-biphenyl]-4-yl)-6-[(1-methyl-1H-imidazol-2-yl)sulfonyl]-1,6-diazabicyclo[6.2.0]decan-10-yl}methanol | Authors: | Tan, G.A, Seeliger, M.A, Welsh, A.J, Maianti, J.P, Liu, D.R. | Deposit date: | 2018-10-09 | Release date: | 2019-04-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.569147 Å) | Cite: | Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nat.Chem.Biol., 15, 2019
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7K1V
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8T7G
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![BU of 8t7g by Molmil](/molmil-images/mine/8t7g) | Structure of the CK variant of Fab F1 (FabC-F1) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, CK variant of Fab F1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-06-20 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T7I
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![BU of 8t7i by Molmil](/molmil-images/mine/8t7i) | Structure of the S1CE variant of Fab F1 (FabS1CE-F1) | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, S1CE variant of Fab F1 heavy chain, ... | Authors: | Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-06-20 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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8T7F
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![BU of 8t7f by Molmil](/molmil-images/mine/8t7f) | Structure of the S1 variant of Fab F1 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, S1 variant of Fab F1 heavy chain, S1 variant of Fab F1 light chain, ... | Authors: | Singer, A.U, Bruce, H.A, Enderle, L, Blazer, L, Adams, J.J, Sicheri, F, Sidhu, S.S. | Deposit date: | 2023-06-20 | Release date: | 2023-11-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes. Protein Sci., 33, 2024
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1LVC
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![BU of 1lvc by Molmil](/molmil-images/mine/1lvc) | Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP | Descriptor: | 3'ANTHRANILOYL-2'-DEOXY-ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, YTTERBIUM (III) ION, ... | Authors: | Shen, Y, Lee, Y.-S, Soelaiman, S, Bergson, P, Lu, D, Chen, A, Beckingham, K, Grabarek, Z, Mrksich, M, Tang, W.-J. | Deposit date: | 2002-05-28 | Release date: | 2002-12-04 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins Embo J., 21, 2002
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5X57
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![BU of 5x57 by Molmil](/molmil-images/mine/5x57) | Structure of GAR domain of ACF7 | Descriptor: | Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5, NICKEL (II) ION | Authors: | Yang, F, Wang, T, Zhang, Y, Wu, X.Y. | Deposit date: | 2017-02-15 | Release date: | 2017-07-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics. Nat Commun, 8, 2017
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