5YAD
| Crystal structure of Marf1 Lotus domain from Mus musculus | Descriptor: | GLYCEROL, Meiosis regulator and mRNA stability factor 1, SULFATE ION | Authors: | Yao, Q.Q, Wu, B.X, Ma, J.B. | Deposit date: | 2017-08-31 | Release date: | 2018-10-03 | Last modified: | 2018-11-14 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5YAA
| Crystal structure of Marf1 NYN domain from Mus musculus | Descriptor: | GLYCEROL, Meiosis regulator and mRNA stability factor 1 | Authors: | Yao, Q.Q, Wu, B.X, Ma, J.B. | Deposit date: | 2017-08-31 | Release date: | 2018-10-03 | Last modified: | 2018-11-14 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Ribonuclease activity of MARF1 controls oocyte RNA homeostasis and genome integrity in mice. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5ZFZ
| Crystal structure of human DUX4 homeodomains bound to A12T DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*TP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*AP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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5ZFW
| Crystal structure of human DUX4 homeodomains bound to A11G DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*GP*AP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*TP*CP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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5ZFY
| Crystal structure of human DUX4 homeodomains bound to A12C DNA mutant | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*CP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*GP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4-like protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-03-07 | Release date: | 2018-10-31 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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5Z6Z
| Crystal structure of human DUX4 homeodomains bound to DNA | Descriptor: | DNA (5'-D(*CP*CP*AP*CP*TP*AP*AP*CP*CP*TP*AP*AP*TP*CP*AP*CP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*GP*TP*GP*AP*TP*TP*AP*GP*GP*TP*TP*AP*GP*TP*GP*G)-3'), Double homeobox protein 4 | Authors: | Li, Y.Y, Wu, B.X, Gan, J.H. | Deposit date: | 2018-01-26 | Release date: | 2018-10-31 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.301 Å) | Cite: | Structural basis for multiple gene regulation by human DUX4. Biochem. Biophys. Res. Commun., 505, 2018
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6A6J
| Crystal structure of Zebra fish Y-box protein1 (YB-1) Cold-shock domain in complex with 6mer m5C RNA | Descriptor: | RNA (5'-R(P*CP*AP*UP*(5MC)P*U)-3'), ZINC ION, Zebra fish Y-box protein1 (YB-1) | Authors: | Zhang, M.M, Wu, B.X, Huang, Y, Ma, J.B. | Deposit date: | 2018-06-28 | Release date: | 2019-06-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.255 Å) | Cite: | RNA 5-Methylcytosine Facilitates the Maternal-to-Zygotic Transition by Preventing Maternal mRNA Decay. Mol.Cell, 75, 2019
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7DNI
| MDA5 CARDs-MAVS CARD polyUb complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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7DNJ
| K63-polyUb MDA5CARDs complex | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Ubiquitin | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | Deposit date: | 2020-12-09 | Release date: | 2021-10-13 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains. Immunity, 54, 2021
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3SVI
| Structure of the Pto-binding domain of HopPmaL generated by limited thermolysin digestion | Descriptor: | CHLORIDE ION, SODIUM ION, SULFATE ION, ... | Authors: | Singer, A.U, Stein, A, Xu, X, Cui, H, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-07-12 | Release date: | 2011-08-10 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Analysis of HopPmaL Reveals the Presence of a Second Adaptor Domain Common to the HopAB Family of Pseudomonas syringae Type III Effectors. Biochemistry, 51, 2012
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1J4I
| crystal structure analysis of the FKBP12 complexed with 000308 small molecule | Descriptor: | 4-METHYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PENTANOIC ACID, FKBP12 | Authors: | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | Deposit date: | 2001-09-30 | Release date: | 2003-06-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design and structure-based study of new potential FKBP12 inhibitors. Biophys.J., 85, 2003
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1J4H
| crystal structure analysis of the FKBP12 complexed with 000107 small molecule | Descriptor: | 3-PHENYL-2-{[4-(TOLUENE-4-SULFONYL)-THIOMORPHOLINE-3-CARBONYL]-AMINO}-PROPIONIC ACID ETHYL ESTER, FKBP12 | Authors: | Li, P, Ding, Y, Wang, L, Wu, B, Shu, C, Li, S, Shen, B, Rao, Z. | Deposit date: | 2001-09-30 | Release date: | 2003-06-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Design and structure-based study of new potential FKBP12 inhibitors. Biophys.J., 85, 2003
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3TJC
| Co-crystal structure of jak2 with thienopyridine 8 | Descriptor: | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | Authors: | Huang, X. | Deposit date: | 2011-08-24 | Release date: | 2011-11-30 | Last modified: | 2011-12-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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3TJD
| co-crystal structure of Jak2 with thienopyridine 19 | Descriptor: | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | Authors: | Huang, X. | Deposit date: | 2011-08-24 | Release date: | 2011-11-30 | Last modified: | 2011-12-28 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors. J.Med.Chem., 54, 2011
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3TJY
| Structure of the Pto-binding domain of HopPmaL generated by limited chymotrypsin digestion | Descriptor: | CHLORIDE ION, Effector protein hopAB3, SULFATE ION | Authors: | Singer, A.U, Stein, A, Xu, X, Cui, H, Joachimiak, A, Edwards, A.M, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-08-25 | Release date: | 2011-09-14 | Last modified: | 2013-01-09 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural analysis of HopPmaL reveals the presence of a second adaptor domain common to the HopAB family of Pseudomonas syringae type III effectors. Biochemistry, 51, 2012
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3D1C
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6L8V
| membrane-bound Bax helix2-helix5 domain | Descriptor: | Apoptosis regulator BAX | Authors: | OuYang, B, Lv, F. | Deposit date: | 2019-11-07 | Release date: | 2020-11-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | An amphipathic Bax core dimer forms part of the apoptotic pore wall in the mitochondrial membrane. Embo J., 40, 2021
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6L0L
| Hydra-1ubq de nova designed by Hydra based on ubiquitin | Descriptor: | Hydra-1ubq | Authors: | Ouyang, B. | Deposit date: | 2019-09-26 | Release date: | 2020-09-30 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Multiobjective heuristic algorithm for de novo protein design in a quantified continuous sequence space. Comput Struct Biotechnol J, 19, 2021
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3F5P
| Complex Structure of Insulin-like Growth Factor Receptor and 3-Cyanoquinoline Inhibitor | Descriptor: | 4-[[3-chloro-4-(1-methylimidazol-2-yl)sulfanyl-phenyl]amino]-7-[3-(2-hydroxyethyl-methyl-amino)propoxy]-6-methoxy-quinoline-3-carbonitrile, Insulin-like growth factor 1 receptor | Authors: | Xu, W, Miller, L.M, Mayer, S.C, Berger, D.M, Boschelli, D.H, Boschelli, F. | Deposit date: | 2008-11-04 | Release date: | 2008-12-30 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Lead identification to generate 3-cyanoquinoline inhibitors of insulin-like growth factor receptor (IGF-1R) for potential use in cancer treatment Bioorg.Med.Chem.Lett., 19, 2009
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8X6F
| Cryo-EM structure of Staphylococcus aureus sigA-dependent RNAP-promoter open complex | Descriptor: | DNA (71-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yuan, L, Xu, L, Liu, Q, Feng, Y. | Deposit date: | 2023-11-21 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase Nat Commun, 2024
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8X6G
| Cryo-EM structure of Staphylococcus aureus sigB-dependent RNAP-promoter open complex | Descriptor: | DNA (70-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Yuan, L, Xu, L, Liu, Q, Feng, Y. | Deposit date: | 2023-11-21 | Release date: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis of promoter recognition by Staphylococcus aureus RNA polymerase Nat Commun, 2024
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7EZM
| Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gq complex | Descriptor: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | Deposit date: | 2021-06-01 | Release date: | 2021-08-25 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
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7EZK
| Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gs complex | Descriptor: | Chimera of Guanine nucleotide-binding protein G(i) subunit alpha-1 and Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Cholecystokinin receptor type A, Cholecystokinin-8, ... | Authors: | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | Deposit date: | 2021-06-01 | Release date: | 2021-08-25 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
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7EZH
| Cryo-EM structure of an activated Cholecystokinin A receptor (CCKAR)-Gi complex | Descriptor: | Cholecystokinin receptor type A, Cholecystokinin-8, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liu, Q.F, Yang, D.H, Zhuang, Y.W, Croll, T.I, Cai, X.Q, Duan, J, Dai, A.T, Yin, W.C, Ye, C.Y, Zhou, F.L, Wu, B.L, Zhao, Q, Xu, H.E, Wang, M.W, Jiang, Y. | Deposit date: | 2021-06-01 | Release date: | 2021-08-25 | Last modified: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor Nat.Chem.Biol., 17, 2021
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7EYL
| Crystal structure of Salmonella enterica ppnP | Descriptor: | Pyrimidine/purine nucleoside phosphorylase | Authors: | Wen, Y, Wu, B.X. | Deposit date: | 2021-05-31 | Release date: | 2022-02-09 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Crystal structures of a new class of pyrimidine/purine nucleoside phosphorylase revealed a Cupin fold. Proteins, 90, 2022
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