Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
3KEH
DownloadVisualize
BU of 3keh by Molmil
Crystal Structure of N370S Glucocerebrosidase mutant at pH 7.4
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wei, R.R, Boucher, S, Pan, C.Q, Edmunds, T.
登録日2009-10-26
公開日2010-10-27
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Glucocerebrosidase Containing the N370S mutation: Implication on Chaperon Therapy
To be Published
3KE0
DownloadVisualize
BU of 3ke0 by Molmil
Crystal structure of N370S Glucocerebrosidase at acidic pH.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wei, R.R, Boucher, S, Pan, C.Q, Edmunds, T.
登録日2009-10-23
公開日2010-10-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of Glucocerebrosidase Containing the N370S Mutation, Implications for Chaperon Therapy
To be Published
2FTX
DownloadVisualize
BU of 2ftx by Molmil
Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain
分子名称: Hypothetical 24.6 kDa protein in ILV2-ADE17 intergenic region, Hypothetical 25.2 kDa protein in AFG3-SEB2 intergenic region, PHOSPHATE ION, ...
著者Wei, R.R, Harrison, S.C.
登録日2006-01-25
公開日2006-06-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Atomic Structure of the kinetochore Spc24p/Spc25p globular domain reveals a novel fold
To be Published
2IGP
DownloadVisualize
BU of 2igp by Molmil
Crystal Structure of Hec1 CH domain
分子名称: BETA-MERCAPTOETHANOL, Retinoblastoma-associated protein HEC
著者Wei, R.R, Harrison, S.C.
登録日2006-09-22
公開日2007-01-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.
Nat.Struct.Mol.Biol., 14, 2007
6O8D
DownloadVisualize
BU of 6o8d by Molmil
Anti-CD28xCD3 CODV Fab bound to CD28
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-CD28xCD3 CODV Fab Heavy chain, ...
著者Lord, D.M, Wei, R.R.
登録日2019-03-09
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.547 Å)
主引用文献Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
To Be Published
6O89
DownloadVisualize
BU of 6o89 by Molmil
Anti-CD28xCD3 CODV Fab
分子名称: Anti-CD28xCD3 CODV-Fab Heavy chain, Anti-CD28xCD3 CODV-Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2019-03-09
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
Nat Cancer, 1, 2020
5I8R
DownloadVisualize
BU of 5i8r by Molmil
aSMase with zinc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ...
著者Zhou, Y.F, Wei, R.R.
登録日2016-02-19
公開日2016-09-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.646 Å)
主引用文献Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
5I85
DownloadVisualize
BU of 5i85 by Molmil
aSMase with zinc and phosphocholine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOCHOLINE, ...
著者Zhou, Y.F, Wei, R.R.
登録日2016-02-18
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
5I81
DownloadVisualize
BU of 5i81 by Molmil
aSMase with zinc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
著者Zhou, Y.F, Wei, R.R.
登録日2016-02-18
公開日2016-09-07
最終更新日2021-03-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
5WHZ
DownloadVisualize
BU of 5whz by Molmil
PGDM1400-10E8v4 CODV Fab
分子名称: Anti-HIV CODV-Fab Heavy chain, Anti-HIV CODV-Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2017-07-18
公開日2017-10-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.549 Å)
主引用文献Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
Science, 358, 2017
6AMM
DownloadVisualize
BU of 6amm by Molmil
CAT192 Fab Insertion Mutant H0/L1
分子名称: CAT192 Fab Heavy chain, CAT192 Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2017-08-10
公開日2018-01-31
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
6AMJ
DownloadVisualize
BU of 6amj by Molmil
CAT192 Fab Wild Type
分子名称: CAT192 Fab heavy chain, CAT192 Fab light chain, DI(HYDROXYETHYL)ETHER, ...
著者Lord, D.M, Wei, R.R.
登録日2017-08-09
公開日2018-01-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
6AO0
DownloadVisualize
BU of 6ao0 by Molmil
CAT192 Fab Insertion Mutant H2/L2
分子名称: CAT192 Fab Heavy chain, CAT192 Fab Light chain, SULFATE ION
著者Lord, D.M, Wei, R.R.
登録日2017-08-15
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
6ANP
DownloadVisualize
BU of 6anp by Molmil
CAT192 Fab Insertion Mutant H5/L0
分子名称: CAT192 Fab Heavy chain, CAT192 Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2017-08-14
公開日2018-01-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
3R02
DownloadVisualize
BU of 3r02 by Molmil
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
分子名称: 7-[(cis-4-aminocyclohexyl)amino]-5-bromo-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1
著者Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R.
登録日2011-03-07
公開日2011-05-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3R04
DownloadVisualize
BU of 3r04 by Molmil
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
分子名称: 5-{6-[(trans-4-aminocyclohexyl)amino]pyrazin-2-yl}-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1
著者Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R.
登録日2011-03-07
公開日2011-05-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
2FV4
DownloadVisualize
BU of 2fv4 by Molmil
NMR solution structure of the yeast kinetochore Spc24/Spc25 globular domain
分子名称: Hypothetical 24.6 kDa protein in ILV2-ADE17 intergenic region, Hypothetical 25.2 kDa protein in AFG3-SEB2 intergenic region
著者Schnell, J.R, Chou, J.J.
登録日2006-01-29
公開日2006-06-13
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Structure of a central component of the yeast kinetochore: the spc24p/spc25p globular domain.
Structure, 6, 2006
4KXZ
DownloadVisualize
BU of 4kxz by Molmil
crystal structure of tgfb2 in complex with GC2008.
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL, GC1008 Heavy Chain, ...
著者Mathieu, M, Moulin, A.G, Wei, R.
登録日2013-05-28
公開日2014-09-24
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.83 Å)
主引用文献Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
4KV5
DownloadVisualize
BU of 4kv5 by Molmil
scFv GC1009 in complex with TGF-beta1.
分子名称: Single-chain variable fragment GC1009, Transforming growth factor beta-1 proprotein
著者Wei, R, Moulin, A.G, Mathieu, M.
登録日2013-05-22
公開日2014-09-24
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of a pan-specific antagonist antibody complexed to different isoforms of TGF beta reveal structural plasticity of antibody-antigen interactions.
Protein Sci., 23, 2014
3VBT
DownloadVisualize
BU of 3vbt by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 4-chloro-2-(1H-pyrazol-3-yl)phenol, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBV
DownloadVisualize
BU of 3vbv by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 8-hydroxyquinoline-2-carboxamide, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBQ
DownloadVisualize
BU of 3vbq by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: (5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBY
DownloadVisualize
BU of 3vby by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: IMIDAZOLE, Serine/threonine-protein kinase pim-1, furan-2-yl(1H-indol-3-yl)methanone
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBW
DownloadVisualize
BU of 3vbw by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 1,3-dioxo-2,3-dihydro-1H-indene-2-carbonitrile, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBX
DownloadVisualize
BU of 3vbx by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 6-bromo-4-hydroxy-2H-chromen-2-one, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012

 

12>

227111

件を2024-11-06に公開中

PDB statisticsPDBj update infoContact PDBjnumon