6AO0

CAT192 Fab Insertion Mutant H2/L2

Summary for 6AO0

• Entry DOI: 10.2210/pdb6ao0/pdb
• Descriptor: CAT192 Fab Light chain, CAT192 Fab Heavy chain, SULFATE ION, ... (4 entities in total)
• Functional Keywords: fab, tgf-beta, protein engineering, antibody engineering, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 48468.47

Authors

Lord, D.M.,Wei, R.R. (deposition date: 2017-08-15, release date: 2018-01-31, Last modification date: 2023-10-04)

• Primary citation: Lord, D.M.,Bird, J.J.,Honey, D.M.,Best, A.,Park, A.,Wei, R.R.,Qiu, H.; Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.; MAbs, 10:444-452, 2018; PubMed: 29333938; DOI: 10.1080/19420862.2018.1426421

Experimental method

X-RAY DIFFRACTION (2.35 Å)