6ANP

CAT192 Fab Insertion Mutant H5/L0

Summary for 6ANP

Entry DOI	10.2210/pdb6anp/pdb
Descriptor	CAT192 Fab Light chain, CAT192 Fab Heavy chain (3 entities in total)
Functional Keywords	fab, tgf-beta, protein engineering, antibody engineering, immune system
Biological source	Homo sapiens More
Total number of polymer chains	4
Total formula weight	96150.45
Authors	Lord, D.M.,Wei, R.R. (deposition date: 2017-08-14, release date: 2018-01-31, Last modification date: 2023-10-04)
Primary citation	Lord, D.M.,Bird, J.J.,Honey, D.M.,Best, A.,Park, A.,Wei, R.R.,Qiu, H. Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody. MAbs, 10:444-452, 2018 Cited by PubMed: 29333938 DOI: 10.1080/19420862.2018.1426421 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation