5WHZ
PGDM1400-10E8v4 CODV Fab
Summary for 5WHZ
Entry DOI | 10.2210/pdb5whz/pdb |
Descriptor | Anti-HIV CODV-Fab Light chain, Anti-HIV CODV-Fab Heavy chain (2 entities in total) |
Functional Keywords | cross-over dual variable immunoglobin, multifunctional biotherapeutic format, bispecific property, codv, hiv, immune system |
Biological source | Homo sapiens More |
Total number of polymer chains | 2 |
Total formula weight | 80401.19 |
Authors | Lord, D.M.,Wei, R.R. (deposition date: 2017-07-18, release date: 2017-10-11, Last modification date: 2023-10-04) |
Primary citation | Xu, L.,Pegu, A.,Rao, E.,Doria-Rose, N.,Beninga, J.,McKee, K.,Lord, D.M.,Wei, R.R.,Deng, G.,Louder, M.,Schmidt, S.D.,Mankoff, Z.,Wu, L.,Asokan, M.,Beil, C.,Lange, C.,Leuschner, W.D.,Kruip, J.,Sendak, R.,Do Kwon, Y.,Zhou, T.,Chen, X.,Bailer, R.T.,Wang, K.,Choe, M.,Tartaglia, L.J.,Barouch, D.H.,O'Dell, S.,Todd, J.P.,Burton, D.R.,Roederer, M.,Connors, M.,Koup, R.A.,Kwong, P.D.,Yang, Z.Y.,Mascola, J.R.,Nabel, G.J. Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques. Science, 358:85-90, 2017 Cited by PubMed: 28931639DOI: 10.1126/science.aan8630 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.549 Å) |
Structure validation
Download full validation report