5VZY
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![BU of 5vzy by Molmil](/molmil-images/mine/5vzy) | Crystal structure of crenezumab Fab in complex with Abeta | 分子名称: | Amyloid beta A4 protein, Crenezumab Fab heavy chain,Immunoglobulin gamma-1 heavy chain, Crenezumab Fab light chain,Immunoblobulin light chain | 著者 | Ultsch, M, Wang, W. | 登録日 | 2017-05-29 | 公開日 | 2017-08-09 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin. Sci Rep, 6, 2016
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5VZX
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![BU of 5vzx by Molmil](/molmil-images/mine/5vzx) | Crystal structure of crenezumab Fab | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Crenezumab Fab heavy chain, ... | 著者 | Ultsch, M, Wang, W. | 登録日 | 2017-05-29 | 公開日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structure of Crenezumab Complex with Abeta Shows Loss of beta-Hairpin. Sci Rep, 6, 2016
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7LFB
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![BU of 7lfb by Molmil](/molmil-images/mine/7lfb) | Fab 7D6 bound to ApoL1 NTD | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Apolipoprotein L1, Fab 7D6 heavy chain, ... | 著者 | Ultsch, M, Kirchhofer, D. | 登録日 | 2021-01-16 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.913 Å) | 主引用文献 | Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol, 4, 2021
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7LF7
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![BU of 7lf7 by Molmil](/molmil-images/mine/7lf7) | Fab 6D12 bound to ApoL1 NTD | 分子名称: | Apolipoprotein L1, ETHANOL, Fab 6D12 heavy chain, ... | 著者 | Ultsch, M, Kirchhofer, D. | 登録日 | 2021-01-15 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.026 Å) | 主引用文献 | Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol, 4, 2021
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7LFA
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![BU of 7lfa by Molmil](/molmil-images/mine/7lfa) | Fab 3B6 bound to ApoL1 NTD | 分子名称: | Apolipoprotein L1, CHLORIDE ION, Fab 3B6 heavy chain, ... | 著者 | Ultsch, M, Kirchhofer, D. | 登録日 | 2021-01-15 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.857 Å) | 主引用文献 | Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol, 4, 2021
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7LF8
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![BU of 7lf8 by Molmil](/molmil-images/mine/7lf8) | Fab 6D12 bound to ApoL2 NTD | 分子名称: | Apolipoprotein L2, Fab 6D12 heavy chain, Fab 6D12 light chain, ... | 著者 | Ultsch, M, Kirchhofer, D. | 登録日 | 2021-01-15 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol, 4, 2021
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7LFD
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![BU of 7lfd by Molmil](/molmil-images/mine/7lfd) | Fab 7D6 bound to ApoL1 BH3 like peptide | 分子名称: | AMMONIUM ION, Apolipoprotein L1 BH3 like peptide, CITRATE ANION, ... | 著者 | Ultsch, M, Kirchhofer, D. | 登録日 | 2021-01-16 | 公開日 | 2021-08-04 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.157 Å) | 主引用文献 | Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol, 4, 2021
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5IXS
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![BU of 5ixs by Molmil](/molmil-images/mine/5ixs) | Lactate Dehydrogenase in complex with hydroxylactam inhibitor compound 9: (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one | 分子名称: | (6R)-3-[(2-chlorophenyl)sulfanyl]-4-hydroxy-6-(3-hydroxyphenyl)-6-(thiophen-3-yl)-5,6-dihydropyridin-2(1H)-one, 1,4,5,6-TETRAHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2016-03-23 | 公開日 | 2016-09-14 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice. Acs Med.Chem.Lett., 7, 2016
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5HEZ
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![BU of 5hez by Molmil](/molmil-images/mine/5hez) | |
7L6K
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![BU of 7l6k by Molmil](/molmil-images/mine/7l6k) | ApoL1 N-terminal domain | 分子名称: | Apolipoprotein L1 | 著者 | Holliday, M.J, Ultsch, M, Moran, P, Fairbrother, W.J, Kirchhofer, D. | 登録日 | 2020-12-23 | 公開日 | 2021-08-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif. Commun Biol, 4, 2021
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6BB1
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![BU of 6bb1 by Molmil](/molmil-images/mine/6bb1) | Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-16 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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6BB2
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![BU of 6bb2 by Molmil](/molmil-images/mine/6bb2) | Lactate Dehydrogenase in complex with inhibitor (S)-5-((2-chlorophenyl)thio)-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (2S)-5-[(2-chlorophenyl)sulfanyl]-6'-(4-fluorophenoxy)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, L-lactate dehydrogenase A chain, LACTIC ACID, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-16 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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6BAG
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![BU of 6bag by Molmil](/molmil-images/mine/6bag) | Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-[(4-fluorophenyl)amino]-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-12 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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6BB0
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![BU of 6bb0 by Molmil](/molmil-images/mine/6bb0) | |
6BAZ
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![BU of 6baz by Molmil](/molmil-images/mine/6baz) | Lactate Dehydrogenase in complex with inhibitor (S)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (3S,6S)-3-[(2-chlorophenyl)sulfanyl]-6-{6-[(4-fluorophenyl)amino]pyridin-2-yl}-6-(thiophen-3-yl)piperidine-2,4-dione, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-16 | 公開日 | 2018-10-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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6BAX
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![BU of 6bax by Molmil](/molmil-images/mine/6bax) | |
6BAD
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![BU of 6bad by Molmil](/molmil-images/mine/6bad) | |
4I77
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![BU of 4i77 by Molmil](/molmil-images/mine/4i77) | Lebrikizumab Fab bound to IL-13 | 分子名称: | Interleukin-13, Lebrikizumab heavy chain, Lebrikizumab light chain | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2012-11-30 | 公開日 | 2013-02-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural Basis of Signaling Blockade by Anti-IL-13 Antibody Lebrikizumab. J.Mol.Biol., 425, 2013
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4R69
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![BU of 4r69 by Molmil](/molmil-images/mine/4r69) | Lactate Dehydrogenase in complex with inhibitor compound 13 | 分子名称: | (5R)-2-[(2-chlorophenyl)sulfanyl]-5-[2,6-dichloro-3-(tetrahydro-2H-pyran-4-ylamino)phenyl]-3-hydroxycyclohex-2-en-1-one, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2014-08-22 | 公開日 | 2014-12-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase. Bioorg.Med.Chem.Lett., 25, 2014
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3HHR
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![BU of 3hhr by Molmil](/molmil-images/mine/3hhr) | |
1L6X
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![BU of 1l6x by Molmil](/molmil-images/mine/1l6x) | FC FRAGMENT OF RITUXIMAB BOUND TO A MINIMIZED VERSION OF THE B-DOMAIN FROM PROTEIN A CALLED Z34C | 分子名称: | IMMUNOGLOBULIN GAMMA-1 HEAVY CHAIN CONSTANT REGION, Minimized B-domain of Protein A Z34C, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Idusogie, E.E, Presta, L.G, Santoro-Gazzano, H, Totpal, K, Wong, P.Y, Ultsch, M, Meng, Y.G, Mullkerrin, M.G. | 登録日 | 2002-03-14 | 公開日 | 2002-04-10 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc. J.Immunol., 164, 2000
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1M1L
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![BU of 1m1l by Molmil](/molmil-images/mine/1m1l) | Human Suppressor of Fused (N-terminal domain) | 分子名称: | Suppressor of Fused | 著者 | Merchant, M, Vajdos, F.F, Ultsch, M, Maun, H.R, Wendt, U, Cannon, J, Lazarus, R.A, de Vos, A.M, de Sauvage, F.J. | 登録日 | 2002-06-19 | 公開日 | 2004-02-03 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Suppressor of fused regulates Gli activity through a dual binding mechanism Mol.Cell.Biol., 24, 2004
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3NZ0
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![BU of 3nz0 by Molmil](/molmil-images/mine/3nz0) | Non-phosphorylated TYK2 kinase with CMP6 | 分子名称: | 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2010-07-15 | 公開日 | 2010-10-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A new regulatory switch in a JAK protein kinase. Proteins, 79, 2011
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3NYX
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![BU of 3nyx by Molmil](/molmil-images/mine/3nyx) | Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide, Non-receptor tyrosine-protein kinase TYK2 | 著者 | Eigenbrot, C, Ultsch, M. | 登録日 | 2010-07-15 | 公開日 | 2010-10-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A new regulatory switch in a JAK protein kinase. Proteins, 79, 2011
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1A22
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![BU of 1a22 by Molmil](/molmil-images/mine/1a22) | HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR | 分子名称: | GROWTH HORMONE, GROWTH HORMONE RECEPTOR | 著者 | De Vos, A.M, Ultsch, M. | 登録日 | 1998-01-15 | 公開日 | 1998-04-29 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural and functional analysis of the 1:1 growth hormone:receptor complex reveals the molecular basis for receptor affinity. J.Mol.Biol., 277, 1998
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