3NZ0

Non-phosphorylated TYK2 kinase with CMP6

Summary for 3NZ0

• Entry DOI: 10.2210/pdb3nz0/pdb
• Related: 3NYX
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (3 entities in total)
• Functional Keywords: protein kinase, tyrosine phosphorylation, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35295.40

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2010-07-15, release date: 2010-10-20, Last modification date: 2023-09-06)

• Primary citation: Tsui, V.,Gibbons, P.,Ultsch, M.,Mortara, K.,Chang, C.,Blair, W.,Pulk, R.,Stanley, M.,Starovasnik, M.,Williams, D.,Lamers, M.,Leonard, P.,Magnuson, S.,Liang, J.,Eigenbrot, C.; A new regulatory switch in a JAK protein kinase.; Proteins, 79:393-401, 2011; PubMed: 21117080; DOI: 10.1002/prot.22889

Experimental method

X-RAY DIFFRACTION (2 Å)