3NZ0

Non-phosphorylated TYK2 kinase with CMP6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Non-receptor tyrosine-protein kinase TYK2	polymer	302	34986.1	1	UniProt (P29597) Pfam (PF07714) In PDB	Homo sapiens (human)
2	A	2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE	non-polymer		309.3	1	Chemie (IZA)
3		water	water		18.0	173	Chemie (HOH)

Sequence modifications

A: 885 - 1176 (UniProt: P29597)

PDB	External Database	Details
Met 882	-	expression tag
Gly 883	-	expression tag
Ser 884	-	expression tag
Asn 1023	Asp 1023	engineered mutation
Arg 1177	-	expression tag
His 1178	-	expression tag
His 1179	-	expression tag
His 1180	-	expression tag
His 1181	-	expression tag
His 1182	-	expression tag
His 1183	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34986.1
Non-Polymers*	Number of molecules	1
	Total formula weight	309.3
All*	Total formula weight	35295.4

*Water molecules are not included.