6BB0

Lactate Dehydrogenase in complex with inhibitor (R)-3-((2-chlorophenyl)thio)-6-(3-((4-fluorophenyl)amino)phenyl)-4-hydroxy-6-(thiophen-3-yl)-5,6-dihydro-2H-pyran-2-one

Summary for 6BB0

• Entry DOI: 10.2210/pdb6bb0/pdb
• Related: 6BAD 6BAG 6BAX 6BAZ
• Descriptor: L-lactate dehydrogenase A chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (7 entities in total)
• Functional Keywords: inhibitor, oxidoreductase, oxidoreductase-inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 151531.53

Authors

Ultsch, M.,Eigenbrot, C. (deposition date: 2017-10-16, release date: 2018-10-24, Last modification date: 2023-11-15)

• Primary citation: Wei, B.,Labadie, S.S.,Robarge, K.,Chen, J.,Chen, Z.,Corson, L.B.,Ding, C.Z.,DiPasquale, A.G.,Dragovich, P.S.,Eigenbrot, C.,Evangelista, M.,Fauber, B.P.,Goa, Z.,Ge, H.,Hitz, A.,Ho, Q.,Lai, K.W.,Liu, W.,Liu, Y.,Li, C.,Ma, S.,Malek, S.,O'Brien, T.,Pang, J.,Peterson, D.,Salphati, L.,Sideris, S.,Ultsch, M.,Yen, I.,Yue, Q.,Zhang, H.,Zhou, A.,Purkey, H.E.; Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.95 Å)