3NYX

Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor

Summary for 3NYX

• Entry DOI: 10.2210/pdb3nyx/pdb
• Related: 3NZ0
• Descriptor: Non-receptor tyrosine-protein kinase TYK2, N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, ... (4 entities in total)
• Functional Keywords: protein kinase, tyrosine phosphorylation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 35715.48

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2010-07-15, release date: 2010-10-20, Last modification date: 2023-09-06)

• Primary citation: Tsui, V.,Gibbons, P.,Ultsch, M.,Mortara, K.,Chang, C.,Blair, W.,Pulk, R.,Stanley, M.,Starovasnik, M.,Williams, D.,Lamers, M.,Leonard, P.,Magnuson, S.,Liang, J.,Eigenbrot, C.; A new regulatory switch in a JAK protein kinase.; Proteins, 79:393-401, 2011; PubMed: 21117080; DOI: 10.1002/prot.22889

Experimental method

X-RAY DIFFRACTION (2.5 Å)