3NYX
Non-phosphorylated TYK2 JH1 domain with Quinoline-Thiadiazole-Thiophene Inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Non-receptor tyrosine-protein kinase TYK2 | polymer | 302 | 35002.1 | 1 | UniProt (P29597) Pfam (PF07714) In PDB | Homo sapiens (human) | |
2 | A | N-{5-[(7-chloroquinolin-4-yl)sulfanyl]-1,3,4-thiadiazol-2-yl}thiophene-2-carboxamide | non-polymer | 404.9 | 1 | Chemie (TZ1) | |||
3 | A | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 2 | Chemie (DTT) | |||
4 | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A: 885 - 1176 (UniProt: P29597)
PDB | External Database | Details |
---|---|---|
Met 882 | - | expression tag |
Gly 883 | - | expression tag |
Ser 884 | - | expression tag |
Ser 1016 | Ala 1016 | conflict |
Asn 1023 | Asp 1023 | engineered mutation |
Arg 1177 | - | expression tag |
His 1178 | - | expression tag |
His 1179 | - | expression tag |
His 1180 | - | expression tag |
His 1181 | - | expression tag |
His 1182 | - | expression tag |
His 1183 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35002.1 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 713.4 | |
All* | Total formula weight | 35715.5 |