6LW8
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![BU of 6lw8 by Molmil](/molmil-images/mine/6lw8) | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | 分子名称: | (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, DNA ligase A, GLYCEROL, ... | 著者 | Ramachandran, R, Afsar, M, Shukla, A. | 登録日 | 2020-02-07 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213, 2021
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6KKV
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![BU of 6kkv by Molmil](/molmil-images/mine/6kkv) | |
6KJM
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![BU of 6kjm by Molmil](/molmil-images/mine/6kjm) | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | 著者 | Ramachandran, R, Shukla, A, Afsar, M. | 登録日 | 2019-07-22 | 公開日 | 2020-07-22 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213, 2021
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3O9O
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![BU of 3o9o by Molmil](/molmil-images/mine/3o9o) | |
4OHF
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![BU of 4ohf by Molmil](/molmil-images/mine/4ohf) | Crystal structure of cytosolic nucleotidase II (LPG0095) in complex with GMP from Legionella pneumophila, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET LGR1 | 分子名称: | Cytosolic IMP-GMP specific 5'-nucleotidase, GUANOSINE-5'-MONOPHOSPHATE, MAGNESIUM ION, ... | 著者 | Srinivisan, B, Forouhar, F, Shukla, A, Sampangi, C, Kulkarni, S, Abashidze, M, Seetharaman, J, Lew, S, Mao, L, Acton, T.B, Xiao, R, Everett, J.K, Montelione, G.M, Tong, L, Balaram, H, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2014-01-17 | 公開日 | 2014-02-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila. Febs J., 281, 2014
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6KDU
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![BU of 6kdu by Molmil](/molmil-images/mine/6kdu) | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | 著者 | Ramachandran, R, Shukla, A, Afsar, M. | 登録日 | 2019-07-02 | 公開日 | 2020-07-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity. Acta Crystallogr D Struct Biol, 77, 2021
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6KSD
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6KRH
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![BU of 6krh by Molmil](/molmil-images/mine/6krh) | Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase A, ... | 著者 | Ramachandran, R, Shukla, A, Afsar, M. | 登録日 | 2019-08-21 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD + -dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity. Acta Crystallogr D Struct Biol, 77, 2021
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6KSC
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6RN1
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![BU of 6rn1 by Molmil](/molmil-images/mine/6rn1) | Structure of N-terminal truncated Plasmodium falciparum IMP-nucleotidase | 分子名称: | IMP-specific 5'-nucleotidase, putative | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | 登録日 | 2019-05-07 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RNH
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![BU of 6rnh by Molmil](/molmil-images/mine/6rnh) | Structure of C-terminal truncated Plasmodium falciparum IMP-nucleotidase | 分子名称: | GLYCEROL, IMP-specific 5'-nucleotidase, putative | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | 登録日 | 2019-05-08 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RMW
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![BU of 6rmw by Molmil](/molmil-images/mine/6rmw) | Structure of N-terminal truncated IMP bound Plasmodium falciparum IMP-nucleotidase | 分子名称: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | 登録日 | 2019-05-07 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RMO
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![BU of 6rmo by Molmil](/molmil-images/mine/6rmo) | Structure of Plasmodium falciparum IMP-nucleotidase | 分子名称: | IMP-specific 5'-nucleotidase, putative | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | 登録日 | 2019-05-07 | 公開日 | 2020-07-15 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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5H5B
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5H56
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![BU of 5h56 by Molmil](/molmil-images/mine/5h56) | ADP and dTDP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, ... | 著者 | Biswas, A, Jeyakanthan, J, Sekar, K, Kuramitsu, S, Yokoyama, S. | 登録日 | 2016-11-04 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate FEBS J., 284, 2017
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5H5K
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![BU of 5h5k by Molmil](/molmil-images/mine/5h5k) | ATP and CMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, ... | 著者 | Biswas, A, Jeyakanthan, J, Sekar, K. | 登録日 | 2016-11-06 | 公開日 | 2017-06-28 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate FEBS J., 284, 2017
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8SEB
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![BU of 8seb by Molmil](/molmil-images/mine/8seb) | Cryo-EM structure of a single loaded human UBA7-UBE2L6-ISG15 adenylate complex | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | 登録日 | 2023-04-08 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.24 Å) | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SEA
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![BU of 8sea by Molmil](/molmil-images/mine/8sea) | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 1) | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | 登録日 | 2023-04-08 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SE9
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![BU of 8se9 by Molmil](/molmil-images/mine/8se9) | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex (Form 2) | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | 登録日 | 2023-04-08 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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8SV8
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![BU of 8sv8 by Molmil](/molmil-images/mine/8sv8) | Cryo-EM structure of a double loaded human UBA7-UBE2L6-ISG15 thioester mimetic complex from a composite map | 分子名称: | ADENOSINE MONOPHOSPHATE, Ubiquitin-like modifier-activating enzyme 7, Ubiquitin-like protein ISG15, ... | 著者 | Afsar, M, Jia, L, Ruben, E.A, Olsen, S.K. | 登録日 | 2023-05-15 | 公開日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.38 Å) | 主引用文献 | Cryo-EM structures of Uba7 reveal the molecular basis for ISG15 activation and E1-E2 thioester transfer. Nat Commun, 14, 2023
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4S2E
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4S35
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![BU of 4s35 by Molmil](/molmil-images/mine/4s35) | AMPPCP and TMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5 | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Biswas, A, Jeyakanthan, J, Sekar, K, Kuramitsu, S, Yokoyama, S. | 登録日 | 2015-01-26 | 公開日 | 2016-01-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate. Febs J., 284, 2017
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6RMD
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![BU of 6rmd by Molmil](/molmil-images/mine/6rmd) | Structure of ATP bound Plasmodium falciparum IMP-nucleotidase | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, IMP-specific 5'-nucleotidase, ... | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | 登録日 | 2019-05-06 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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6RME
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![BU of 6rme by Molmil](/molmil-images/mine/6rme) | Structure of IMP bound Plasmodium falciparum IMP-nucleotidase mutant D172N | 分子名称: | GLYCEROL, IMP-specific 5'-nucleotidase, putative, ... | 著者 | Carrique, L, Ballut, L, Violot, S, Aghajari, N. | 登録日 | 2019-05-06 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structure and catalytic regulation of Plasmodium falciparum IMP specific nucleotidase. Nat Commun, 11, 2020
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5XBH
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![BU of 5xbh by Molmil](/molmil-images/mine/5xbh) | |