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4S35

AMPPCP and TMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5

Summary for 4S35
Entry DOI10.2210/pdb4s35/pdb
Related2PBR
DescriptorThymidylate kinase, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, THYMIDINE-5'-PHOSPHATE, ... (7 entities in total)
Functional Keywordstransferase, atp binding, tmp binding
Biological sourceAquifex aeolicus
Total number of polymer chains2
Total formula weight46717.56
Authors
Biswas, A.,Jeyakanthan, J.,Sekar, K.,Kuramitsu, S.,Yokoyama, S. (deposition date: 2015-01-26, release date: 2016-01-27, Last modification date: 2023-09-20)
Primary citationBiswas, A.,Shukla, A.,Chaudhary, S.K.,Santhosh, R.,Jeyakanthan, J.,Sekar, K.
Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate.
Febs J., 284:2527-2544, 2017
Cited by
PubMed: 28627020
DOI: 10.1111/febs.14140
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.55 Å)
Structure validation

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