4S35
AMPPCP and TMP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004798 | molecular_function | thymidylate kinase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006227 | biological_process | dUDP biosynthetic process |
A | 0006233 | biological_process | dTDP biosynthetic process |
A | 0006235 | biological_process | dTTP biosynthetic process |
A | 0009165 | biological_process | nucleotide biosynthetic process |
A | 0016301 | molecular_function | kinase activity |
A | 0016310 | biological_process | phosphorylation |
A | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
B | 0004798 | molecular_function | thymidylate kinase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006227 | biological_process | dUDP biosynthetic process |
B | 0006233 | biological_process | dTDP biosynthetic process |
B | 0006235 | biological_process | dTTP biosynthetic process |
B | 0009165 | biological_process | nucleotide biosynthetic process |
B | 0016301 | molecular_function | kinase activity |
B | 0016310 | biological_process | phosphorylation |
B | 0046940 | biological_process | nucleoside monophosphate phosphorylation |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE ACP A 201 |
Chain | Residue |
A | ASP9 |
A | GLU147 |
A | GLY176 |
A | GLU178 |
A | TMP202 |
A | MG203 |
A | HOH301 |
A | HOH302 |
A | HOH303 |
A | HOH397 |
A | HOH398 |
A | GLY10 |
A | HOH399 |
A | HOH404 |
A | HOH407 |
A | HOH408 |
A | HOH485 |
A | SER11 |
A | GLY12 |
A | LYS13 |
A | THR14 |
A | THR15 |
A | ARG90 |
A | ARG139 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE TMP A 202 |
Chain | Residue |
A | ASP9 |
A | GLU36 |
A | PRO37 |
A | ARG47 |
A | PHE64 |
A | ARG90 |
A | THR95 |
A | TYR98 |
A | GLN99 |
A | ASN144 |
A | PHE146 |
A | ACP201 |
A | HOH302 |
A | HOH303 |
A | HOH408 |
A | HOH409 |
A | HOH457 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 203 |
Chain | Residue |
A | THR14 |
A | ACP201 |
A | HOH301 |
A | HOH302 |
A | HOH303 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 204 |
Chain | Residue |
A | TYR29 |
A | PHE30 |
A | ASP83 |
A | ASN148 |
A | GLU150 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE EDO A 205 |
Chain | Residue |
A | ASP134 |
A | ILE135 |
A | ARG138 |
A | HOH359 |
site_id | AC6 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE ACP B 201 |
Chain | Residue |
B | ASP9 |
B | GLY10 |
B | SER11 |
B | GLY12 |
B | LYS13 |
B | THR14 |
B | THR15 |
B | ARG90 |
B | ARG139 |
B | GLU147 |
B | GLY176 |
B | GLU177 |
B | GLU178 |
B | TMP202 |
B | MG203 |
B | HOH301 |
B | HOH302 |
B | HOH303 |
B | HOH323 |
B | HOH369 |
B | HOH372 |
B | HOH374 |
B | HOH375 |
B | HOH376 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE TMP B 202 |
Chain | Residue |
B | ASP9 |
B | GLU36 |
B | PRO37 |
B | ARG47 |
B | PHE64 |
B | ARG90 |
B | THR95 |
B | TYR98 |
B | GLN99 |
B | ASN144 |
B | PHE146 |
B | ACP201 |
B | HOH301 |
B | HOH303 |
B | HOH323 |
B | HOH358 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 203 |
Chain | Residue |
B | HOH303 |
B | THR14 |
B | ACP201 |
B | HOH301 |
B | HOH302 |
site_id | AC9 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE MG B 204 |
Chain | Residue |
B | VAL133 |
B | GLU153 |
B | ARG156 |
site_id | BC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE CL B 205 |
Chain | Residue |
B | ASN114 |
site_id | BC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE EDO B 206 |
Chain | Residue |
A | VAL195 |
B | GLU179 |
Functional Information from PROSITE/UniProt
site_id | PS01331 |
Number of Residues | 13 |
Details | THYMIDYLATE_KINASE Thymidylate kinase signature. ILDRFvlSTiAYQ |
Chain | Residue | Details |
A | ILE87-GLN99 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255 |
Chain | Residue | Details |
A | GLY7 | |
B | GLY7 |