5H56

ADP and dTDP bound Crystal structure of thymidylate kinase (aq_969) from Aquifex Aeolicus VF5

Summary for 5H56

Related5H5B 5H5K
DescriptorThymidylate kinase, ADENOSINE-5'-DIPHOSPHATE, THYMIDINE-5'-DIPHOSPHATE, ... (7 entities in total)
Functional Keywordskinase, transferase, rossmann fold, product-bound
Biological sourceAquifex aeolicus (strain VF5)
Total number of polymer chains2
Total molecular weight46927.03
Authors
Biswas, A.,Jeyakanthan, J.,Sekar, K.,Kuramitsu, S.,Yokoyama, S. (deposition date: 2016-11-04, release date: 2017-06-28, Last modification date: 2017-08-30)
Primary citation
Biswas, A.,Shukla, A.,Chaudhary, S.K.,Santhosh, R.,Jeyakanthan, J.,Sekar, K.
Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate
FEBS J., 284:2527-2544, 2017
PubMed: 28627020 (PDB entries with the same primary citation)
DOI: 10.1111/febs.14140
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeRamachandran outliersSidechain outliersRSRZ outliers0.193001.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution