6LW8

Structural basis for domain rotation during adenylation of active site K123 and fragment library screening against NAD+ -dependent DNA ligase from Mycobacterium tuberculosis

Summary for 6LW8

Entry DOI	10.2210/pdb6lw8/pdb
Descriptor	DNA ligase A, GLYCEROL, (4R)-4-(4-fluorophenyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine, ... (5 entities in total)
Functional Keywords	ligase
Biological source	Mycobacterium tuberculosis H37Rv
Total number of polymer chains	1
Total formula weight	38493.60
Authors	Ramachandran, R.,Afsar, M.,Shukla, A. (deposition date: 2020-02-07, release date: 2021-02-10, Last modification date: 2023-11-29)
Primary citation	Shukla, A.,Afsar, M.,Kumar, N.,Kumar, S.,Ramachandran, R. Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD + -dependent DNA ligase A. J.Struct.Biol., 213:107655-107655, 2021 Cited by PubMed: 33197566 DOI: 10.1016/j.jsb.2020.107655 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.401 Å)

Structure validation