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Crystal structure of human PPARgamma ligand binding domain Y473E mutant in complex with GW1929
分子名称:	(2~{S})-3-[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]-2-[[2-(phenylcarbonyl)phenyl]amino]propanoic acid, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2020-08-10
公開日	2021-03-03
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.15 Å)
主引用文献	Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021

8ZFQ

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and BVT.13
分子名称:	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.49 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

8ZFO

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and nTZDpa
分子名称:	2-chloro-5-nitro-N-phenylbenzamide, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
実験手法	X-RAY DIFFRACTION (3.15 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

8ZFR

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and nTZDpa
分子名称:	2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 5-CHLORO-1-(4-CHLOROBENZYL)-3-(PHENYLTHIO)-1H-INDOLE-2-CARBOXYLIC ACID, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
実験手法	X-RAY DIFFRACTION (2.73 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

8ZFP

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and MRL24
分子名称:	(2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-chloro-5-nitro-N-phenylbenzamide, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
実験手法	X-RAY DIFFRACTION (2.48 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

8ZFT

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and SR1664
分子名称:	2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 4'-[(2,3-dimethyl-5-{[(1S)-1-(4-nitrophenyl)ethyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

8ZFN

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and BVT.13
分子名称:	2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, 2-chloro-5-nitro-N-phenylbenzamide, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (2.54 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

8ZFS

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and MRL24
分子名称:	(2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2024-05-08
公開日	2024-08-07
実験手法	X-RAY DIFFRACTION (2.56 Å)
主引用文献	Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024

6MD4

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Rosiglitazone and Oleic acid
分子名称:	2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), OLEIC ACID, ...
著者	Shang, J, Kojetin, D.J.
登録日	2018-09-03
公開日	2019-01-09
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.24 Å)
主引用文献	Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018

6MD1

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Oleic acid
分子名称:	2-chloro-5-nitro-N-phenylbenzamide, OLEIC ACID, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2018-09-03
公開日	2019-01-09
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018

6MCZ

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Arachidonic Acid
分子名称:	ARACHIDONIC ACID, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2018-09-03
公開日	2019-01-09
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018

8FHE

Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662
分子名称:	2-chloro-5-nitro-N-phenylbenzamide, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2022-12-14
公開日	2024-03-20
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and GW9662 To Be Published

8FHG

Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437
分子名称:	N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide, Nuclear receptor corepressor 1, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2022-12-14
公開日	2024-03-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal structure of PPARgamma ligand-binding domain in complex with N-CoR peptide and ZINC5672437 To Be Published

8FHF

Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437
分子名称:	N-(4-carbamoylphenyl)-2-chloro-5-nitrobenzamide, Peroxisome proliferator-activated receptor gamma, nonanoic acid
著者	Shang, J, Kojetin, D.J.
登録日	2022-12-14
公開日	2024-03-20
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Crystal structure of PPARgamma ligand-binding domain in complex with ZINC5672437 To Be Published

4OUH

Crystal structure of the FP domain of Human PI31 Proteasome Inhibitor
分子名称:	Proteasome inhibitor PI31 subunit
著者	Shang, J, Huang, X, Du, Z.
登録日	2014-02-17
公開日	2015-02-25
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	The FP domains of PI31 and Fbxo7 have the same protein fold but very different modes of protein-protein interaction. J.Biomol.Struct.Dyn., 33, 2015

5UGM

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Edaglitazone
分子名称:	(5R)-5-({4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}methyl)-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma, nonanoic acid
著者	Shang, J, Kojetin, D.J.
登録日	2017-01-09
公開日	2018-01-17
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018

6PDZ

Crystal structure of PPARgamma ligand binding domain in complex with SMRT peptide and inverse agonist T0070907
分子名称:	2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, Nuclear receptor corepressor 2, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2019-06-19
公開日	2020-03-04
最終更新日	2024-10-09
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11, 2020

6ONI

Crystal structure of PPARgamma ligand binding domain in complex with N-CoR peptide and inverse agonist T0070907
分子名称:	2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, NCOR isoform c, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2019-04-22
公開日	2020-03-04
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11, 2020

6ONJ

Crystal structure of PPARgamma ligand binding domain in complex with TRAP220 peptide and agonist rosiglitazone
分子名称:	2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), Mediator of RNA polymerase II transcription subunit 1, ...
著者	Shang, J, Kojetin, D.J.
登録日	2019-04-22
公開日	2020-03-04
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11, 2020

6MD2

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Arachidonic acid
分子名称:	2-chloro-5-nitro-N-phenylbenzamide, ARACHIDONIC ACID, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2018-09-03
公開日	2019-01-09
最終更新日	2024-10-09
実験手法	X-RAY DIFFRACTION (2.2 Å)
主引用文献	Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018

6MD0

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Oleic Acid
分子名称:	OLEIC ACID, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2018-09-03
公開日	2019-01-09
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7, 2018

6VSJ

Cryo-electron microscopy structure of mouse coronavirus spike protein complexed with its murine receptor
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Carcinoembryonic antigen-related cell adhesion molecule 1, Spike glycoprotein
著者	Shang, J, Wan, Y.S, Liu, C, Yount, B, Gully, K, Yang, Y, Auerbach, A, Peng, G.Q, Baric, R, Li, F.
登録日	2020-02-11
公開日	2020-03-04
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.94 Å)
主引用文献	Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. Plos Pathog., 16, 2020

6VW1

Structure of SARS-CoV-2 chimeric receptor-binding domain complexed with its receptor human ACE2
分子名称:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Shang, J, Ye, G, Shi, K, Wan, Y.S, Aihara, H, Li, F.
登録日	2020-02-18
公開日	2020-03-04
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.68 Å)
主引用文献	Structural basis of receptor recognition by SARS-CoV-2. Nature, 581, 2020

6VZO

Crystal structure of human PPARgamma ligand binding domain (Protein delipidated by denature and refold)
分子名称:	Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2020-02-28
公開日	2021-03-03
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.27 Å)
主引用文献	Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021

6VZM

Crystal structure of human PPARgamma ligand binding domain Y473E mutant in complex with Darglitazone
分子名称:	(5Z)-5-({4-[3-(5-methyl-2-phenyl-1,3-oxazol-4-yl)propanoyl]phenyl}methylidene)-1,3-thiazolidine-2,4-dione, Peroxisome proliferator-activated receptor gamma
著者	Shang, J, Kojetin, D.J.
登録日	2020-02-28
公開日	2021-03-03
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Structural mechanism underlying ligand binding and activation of PPAR gamma. Structure, 29, 2021

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