6ONJ
Crystal structure of PPARgamma ligand binding domain in complex with TRAP220 peptide and agonist rosiglitazone
Summary for 6ONJ
Entry DOI | 10.2210/pdb6onj/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, Mediator of RNA polymerase II transcription subunit 1, TRAP220 Coactivator Peptide, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total) |
Functional Keywords | nuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-agonist complex, transcription/agonist |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 34004.46 |
Authors | Shang, J.,Kojetin, D.J. (deposition date: 2019-04-22, release date: 2020-03-04, Last modification date: 2023-10-11) |
Primary citation | Shang, J.,Mosure, S.A.,Zheng, J.,Brust, R.,Bass, J.,Nichols, A.,Solt, L.A.,Griffin, P.R.,Kojetin, D.J. A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11:956-956, 2020 Cited by PubMed: 32075969DOI: 10.1038/s41467-020-14750-x PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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