6ONJ

Crystal structure of PPARgamma ligand binding domain in complex with TRAP220 peptide and agonist rosiglitazone

Summary for 6ONJ

Entry DOI	10.2210/pdb6onj/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, Mediator of RNA polymerase II transcription subunit 1, TRAP220 Coactivator Peptide, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ... (4 entities in total)
Functional Keywords	nuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-agonist complex, transcription/agonist
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	34004.46
Authors	Shang, J.,Kojetin, D.J. (deposition date: 2019-04-22, release date: 2020-03-04, Last modification date: 2023-10-11)
Primary citation	Shang, J.,Mosure, S.A.,Zheng, J.,Brust, R.,Bass, J.,Nichols, A.,Solt, L.A.,Griffin, P.R.,Kojetin, D.J. A molecular switch regulating transcriptional repression and activation of PPAR gamma. Nat Commun, 11:956-956, 2020 Cited by PubMed: 32075969 DOI: 10.1038/s41467-020-14750-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation