8ZFT
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and SR1664
Summary for 8ZFT
Entry DOI | 10.2210/pdb8zft/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 4'-[(2,3-dimethyl-5-{[(1S)-1-(4-nitrophenyl)ethyl]carbamoyl}-1H-indol-1-yl)methyl]biphenyl-2-carboxylic acid (3 entities in total) |
Functional Keywords | nuclear receptors, tzds, drug design, therapeutic targets, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64549.57 |
Authors | |
Primary citation | Shang, J.,Kojetin, D.J. Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024 Cited by DOI: 10.7554/eLife.99782.1PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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