6MD1

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Oleic acid

Summary for 6MD1

DescriptorPeroxisome proliferator-activated receptor gamma, OLEIC ACID, 2-chloro-5-nitro-N-phenylbenzamide, ... (4 entities in total)
Functional Keywordsnuclear receptors, tzds, drug design, therapeutic targets, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight63740.64
Authors
Shang, J.,Kojetin, D.J. (deposition date: 2018-09-03, release date: 2019-01-09)
Primary citation
Shang, J.,Brust, R.,Mosure, S.A.,Bass, J.,Munoz-Tello, P.,Lin, H.,Hughes, T.S.,Tang, M.,Ge, Q.,Kamekencka, T.M.,Kojetin, D.J.
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma.
Elife, 7:-, 2018
PubMed: 30575522 (PDB entries with the same primary citation)
DOI: 10.7554/eLife.43320
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26617 2.0% 2.8% 7.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6md1
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Molmil generated image of 6md1
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Molmil generated image of 6md1
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More Biological unit images

Molmil generated image of 6md1
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Molmil generated image of 6md1
rotated about x axis by 90°
Molmil generated image of 6md1
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6md1.pdb1.gz [46.74 KB])
Coordinate files for Biological unit (6md1.pdb2.gz [45.95 KB])
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