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6MD1

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Oleic acid

Summary for 6MD1
Entry DOI10.2210/pdb6md1/pdb
DescriptorPeroxisome proliferator-activated receptor gamma, OLEIC ACID, 2-chloro-5-nitro-N-phenylbenzamide, ... (4 entities in total)
Functional Keywordsnuclear receptors, tzds, drug design, therapeutic targets, transcription
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight63740.64
Authors
Shang, J.,Kojetin, D.J. (deposition date: 2018-09-03, release date: 2019-01-09, Last modification date: 2023-10-11)
Primary citationShang, J.,Brust, R.,Mosure, S.A.,Bass, J.,Munoz-Tello, P.,Lin, H.,Hughes, T.S.,Tang, M.,Ge, Q.,Kamekencka, T.M.,Kojetin, D.J.
Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma.
Elife, 7:-, 2018
Cited by
PubMed: 30575522
DOI: 10.7554/eLife.43320
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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