8ZFS
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and MRL24
Summary for 8ZFS
Entry DOI | 10.2210/pdb8zfs/pdb |
Descriptor | Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, (2S)-2-(3-{[1-(4-METHOXYBENZOYL)-2-METHYL-5-(TRIFLUOROMETHOXY)-1H-INDOL-3-YL]METHYL}PHENOXY)PROPANOIC ACID, ... (4 entities in total) |
Functional Keywords | nuclear receptors, tzds, drug design, therapeutic targets, transcription |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 64509.34 |
Authors | |
Primary citation | Shang, J.,Kojetin, D.J. Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma. Elife, 2024 Cited by DOI: 10.7554/eLife.99782.1PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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