6MD2
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with GW9662 and Arachidonic acid
Summary for 6MD2
| Entry DOI | 10.2210/pdb6md2/pdb |
| Descriptor | Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-phenylbenzamide, ARACHIDONIC ACID, ... (4 entities in total) |
| Functional Keywords | nuclear receptors, tzds, drug design, therapeutic targets, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 64061.32 |
| Authors | Shang, J.,Kojetin, D.J. (deposition date: 2018-09-03, release date: 2019-01-09, Last modification date: 2023-10-11) |
| Primary citation | Shang, J.,Brust, R.,Mosure, S.A.,Bass, J.,Munoz-Tello, P.,Lin, H.,Hughes, T.S.,Tang, M.,Ge, Q.,Kamekencka, T.M.,Kojetin, D.J. Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPAR gamma. Elife, 7:-, 2018 Cited by PubMed: 30575522DOI: 10.7554/eLife.43320 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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