8ZFQ

Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with T0070907 and BVT.13

Summary for 8ZFQ

• Entry DOI: 10.2210/pdb8zfq/pdb
• Descriptor: Peroxisome proliferator-activated receptor gamma, 2-chloro-5-nitro-N-(pyridin-4-yl)benzamide, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: nuclear receptors, tzds, drug design, therapeutic targets, transcription
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 64262.77

Authors

Shang, J.,Kojetin, D.J. (deposition date: 2024-05-08, release date: 2024-08-07)

• Primary citation: Shang, J.,Kojetin, D.J.; Unanticipated mechanisms of covalent inhibitor and synthetic ligand cobinding to PPAR gamma.; Elife, 2024; DOI: 10.7554/eLife.99782.1

Experimental method

X-RAY DIFFRACTION (2.49 Å)