7T2Q
 
 | | PEGylated Calmodulin-1 (K148U) | | 分子名称: | CALCIUM ION, Calmodulin-1, MAGNESIUM ION, ... | | 著者 | Mackay, J.P, Payne, R.J, Patel, K, Dowman, L.J. | | 登録日 | 2021-12-06 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine.
Nat Commun, 13, 2022
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7TO9
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7TO7
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2HI3
 | | Solution structure of the homeodomain-only protein HOP | | 分子名称: | Homeodomain-only protein | | 著者 | Mackay, J.P, Kook, H, Epstein, J.A, Simpson, R.J, Yung, W.W. | | 登録日 | 2006-06-28 | | 公開日 | 2007-01-02 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Analysis of the structure and function of the transcriptional coregulator HOP
Biochemistry, 45, 2006
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2MPL
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1K2F
 | | siah, Seven In Absentia Homolog | | 分子名称: | BETA-MERCAPTOETHANOL, ZINC ION, siah-1A protein | | 著者 | Polekhina, G, House, C.M, Traficante, N, Mackay, J.P, Relaix, F, Sassoon, D.A, Parker, M.W, Bowtell, D.D.L. | | 登録日 | 2001-09-26 | | 公開日 | 2001-12-28 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signaling.
Nat.Struct.Biol., 9, 2002
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1JN7
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7JX7
 | | BRD2-BD2 in complex with a diacetylated-H2A.Z peptide | | 分子名称: | Bromodomain-containing protein 2, Diacetylated-H2A.Z peptide | | 著者 | Patel, K, Low, J.K.K, Mackay, J.P, Solomon, P.D. | | 登録日 | 2020-08-26 | | 公開日 | 2020-12-09 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The bromodomains of BET family proteins can recognize diacetylated histone H2A.Z.
Protein Sci., 30, 2021
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7L4Z
 | | Structure of SARS-CoV-2 spike RBD in complex with cyclic peptide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACE-DTY-LYS-ALA-GLY-VAL-VAL-TYR-GLY-TYR-ASN-ALA-TRP-ILE-ARG-CYS-NH2, Spike protein S1 | | 著者 | Christie, M, Mackay, J.P, Passioura, T, Payne, R.J. | | 登録日 | 2020-12-21 | | 公開日 | 2021-06-30 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.96 Å) | | 主引用文献 | Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein Using mRNA Display.
Acs Cent.Sci., 7, 2021
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6PTL
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8D4Y
 | | C-terminal SANT-SLIDE domain of human Chromodomain-helicase-DNA-binding protein 4 (CHD4) | | 分子名称: | Chromodomain-helicase-DNA-binding protein 4 | | 著者 | Moghaddas Sani, H, Deshpande, C.N, Panjikar, S, Patel, K, Mackay, J.P. | | 登録日 | 2022-06-03 | | 公開日 | 2022-12-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families.
Nat Commun, 13, 2022
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8CV5
 | | Peptide 4.2B in complex with BRD3.2 | | 分子名称: | ACETYL GROUP, AMINO GROUP, Bromodomain-containing protein 3, ... | | 著者 | Franck, C, Mackay, J.P. | | 登録日 | 2022-05-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
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8CV7
 | | Peptide 2.2E in complex with BRD2-BD2 | | 分子名称: | ACETYL GROUP, AMINO GROUP, Isoform 3 of Bromodomain-containing protein 2, ... | | 著者 | Franck, C, Mackay, J.P. | | 登録日 | 2022-05-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
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8CV4
 | | Peptide 4.2C in complex with BRD4.2 | | 分子名称: | ACETYL GROUP, AMINO GROUP, BRD4 protein, ... | | 著者 | Franck, C, Mackay, J.P. | | 登録日 | 2022-05-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
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8CV6
 | | Peptide 4.2B in complex with BRD4.2 | | 分子名称: | ACETYL GROUP, AMINO GROUP, BRD4 protein, ... | | 著者 | Franck, C, Mackay, J.P. | | 登録日 | 2022-05-18 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins.
Structure, 31, 2023
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8DNQ
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3G9Y
 | | Crystal structure of the second zinc finger from ZRANB2/ZNF265 bound to 6 nt ssRNA sequence AGGUAA | | 分子名称: | RNA (5'-R(*AP*GP*GP*UP*AP*A)-3'), ZINC ION, Zinc finger Ran-binding domain-containing protein 2 | | 著者 | Loughlin, F.E, McGrath, A.P, Lee, M, Guss, J.M, Mackay, J.P. | | 登録日 | 2009-02-15 | | 公開日 | 2009-03-03 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The zinc fingers of the SR-like protein ZRANB2 are single-stranded RNA-binding domains that recognize 5' splice site-like sequences
Proc.Natl.Acad.Sci.USA, 106, 2009
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6OM5
 | | Structure of a haemophore from Haemophilus haemolyticus | | 分子名称: | CHLORIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Torrado, M, Walshe, J.L, Mackay, J.P, Guss, J.M, Gell, D.A. | | 登録日 | 2019-04-18 | | 公開日 | 2019-12-04 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A heme-binding protein produced by Haemophilus haemolyticus inhibits non-typeable Haemophilus influenzae.
Mol.Microbiol., 113, 2020
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7UQT
 | | Solution NMR structure of hexahistidine tagged QseM (6H-QseM) | | 分子名称: | Quorum sensing master protein | | 著者 | Hall, D.A, Solomon, P.D, Bond, C.S, Ramsay, J.P, Mackay, J.P. | | 登録日 | 2022-04-20 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria.
Nucleic Acids Res., 51, 2023
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3OVU
 | | Crystal Structure of Human Alpha-Haemoglobin Complexed with AHSP and the First NEAT Domain of IsdH from Staphylococcus aureus | | 分子名称: | Alpha-hemoglobin-stabilizing protein, Hemoglobin subunit alpha, Iron-regulated surface determinant protein H, ... | | 著者 | Jacques, D.A, Krishna Kumar, K, Caradoc-Davies, T.T, Langley, D.B, Mackay, J.P, Guss, J.M, Gell, D.A. | | 登録日 | 2010-09-17 | | 公開日 | 2011-09-21 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.83 Å) | | 主引用文献 | A new haem pocket structure in alpha-haemoglobin
To be Published
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4IS1
 | | Crystal structure of ZNF217 bound to DNA | | 分子名称: | 5'-D(*AP*AP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', 5'-D(*TP*TP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', CHLORIDE ION, ... | | 著者 | Vandevenne, M.S, Jacques, D.A, Guss, J.M, Mackay, J.P. | | 登録日 | 2013-01-16 | | 公開日 | 2013-02-27 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | New insights into DNA recognition by zinc fingers revealed by structural analysis of the oncoprotein ZNF217.
J.Biol.Chem., 288, 2013
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1M3V
 | | FLIN4: Fusion of the LIM binding domain of Ldb1 and the N-terminal LIM domain of LMO4 | | 分子名称: | ZINC ION, fusion of the LIM interacting domain of ldb1 and the N-terminal LIM domain of LMO4 | | 著者 | Deane, J.E, Mackay, J.P, Kwan, A.H.Y, Sum, E.Y, Visvader, J.E, Matthews, J.M. | | 登録日 | 2002-06-30 | | 公開日 | 2003-05-13 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4
EMBO J., 22, 2003
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3UK3
 | | Crystal structure of ZNF217 bound to DNA | | 分子名称: | 5'-D(*AP*AP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', 5'-D(*TP*TP*TP*GP*CP*AP*GP*AP*AP*TP*CP*GP*AP*TP*TP*CP*TP*GP*CP*A)-3', CHLORIDE ION, ... | | 著者 | Vandevenne, M.S, Jacques, D.A, Guss, J.M, Mackay, J.P. | | 登録日 | 2011-11-08 | | 公開日 | 2012-12-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Rediscovering DNA recognition by classical Zinc Fingers.
To be Published
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6BGH
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6BGG
 | | Solution NMR structures of the BRD3 ET domain in complex with a CHD4 peptide | | 分子名称: | Bromodomain-containing protein 3, CHD4 | | 著者 | Wai, D.C.C, Szyszka, T.N, Campbell, A.E, Kwong, C, Wilkinson-White, L, Silva, A.P.G, Low, J.K.K, Kwan, A.H, Gamsjaeger, R, Lu, B, Vakoc, C.R, Blobel, G.A, Mackay, J.P. | | 登録日 | 2017-10-28 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The BRD3 ET domain recognizes a short peptide motif through a mechanism that is conserved across chromatin remodelers and transcriptional regulators.
J. Biol. Chem., 293, 2018
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