6DZP
 
 | Cryo-EM Structure of Mycobacterium smegmatis C(minus) 50S ribosomal subunit | 分子名称: | 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ... | 著者 | Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. | 登録日 | 2018-07-05 | 公開日 | 2018-10-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DZK
 
 | Cryo-EM Structure of Mycobacterium smegmatis C(minus) 30S ribosomal subunit with MPY | 分子名称: | 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. | 登録日 | 2018-07-05 | 公開日 | 2018-09-19 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6DZI
 
 | Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex | 分子名称: | 16S rRNA, 23 S rRNA (3119-MER), 30S ribosomal protein S10, ... | 著者 | Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A. | 登録日 | 2018-07-05 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Zinc depletion induces ribosome hibernation in mycobacteria. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4G35
 
 | Mcl-1 in complex with a biphenyl cross-linked Noxa peptide. | 分子名称: | 4,4'-bis(bromomethyl)biphenyl, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked) | 著者 | Drake, E, Edwardraja, S, Lin, Q, Gulick, A.M. | 登録日 | 2012-07-13 | 公開日 | 2012-12-05 | 最終更新日 | 2024-11-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J.Am.Chem.Soc., 134, 2012
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2PY2
 
 | Structure of Herring Type II Antifreeze Protein | 分子名称: | Antifreeze protein type II, CALCIUM ION | 著者 | Liu, Y, Li, Z, Lin, Q, Seetharaman, J, Sivaraman, J, Hew, C.-L. | 登録日 | 2007-05-15 | 公開日 | 2007-06-26 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure and Evolutionary Origin of Ca-Dependent Herring Type II Antifreeze Protein. PLoS ONE, 2, 2007
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4R05
 
 | Crystal structure of the refolded DENV3 methyltransferase | 分子名称: | Nonstructural protein NS5 | 著者 | Brecher, M.B, Li, Z, Zhang, J, Chen, H, Lin, Q, Liu, B, Li, H.M. | 登録日 | 2014-07-29 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase. Protein Sci., 24, 2015
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8Y2R
 
 | NMR Solution Structure of the 2:1 Coptisine-ATF4-G4 Complex | 分子名称: | 6,7-dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinolin-5-ium, DNA (5'-D(*TP*AP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*AP*GP*GP*GP*AP*GP*C*(LIG)*(LIG))-3') | 著者 | Xiao, C.M, Li, Y.P, Liu, Y.S, Dong, R.F, He, X.Y, Lin, Q, Zang, X, Wang, K.B, Xia, Y.Z, Kong, L.Y. | 登録日 | 2024-01-27 | 公開日 | 2024-12-04 | 最終更新日 | 2025-06-18 | 実験手法 | SOLUTION NMR | 主引用文献 | Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex. Adv Sci, 11, 2024
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8JMZ
 
 | FGFR1 kinase domain with sulfatinib | 分子名称: | Fibroblast growth factor receptor 1, GLYCEROL, SULFATE ION, ... | 著者 | Chen, X.J, Lin, Q.M, Chen, Y.H. | 登録日 | 2023-06-05 | 公開日 | 2024-03-27 | 最終更新日 | 2024-11-20 | 実験手法 | X-RAY DIFFRACTION (1.988 Å) | 主引用文献 | Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R. Commun Chem, 7, 2024
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8JOT
 
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6A0Z
 
 | Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 13D4, Fab Heavy Chain, ... | 著者 | Li, S, Li, T. | 登録日 | 2018-06-06 | 公開日 | 2018-06-20 | 最終更新日 | 2024-10-30 | 実験手法 | X-RAY DIFFRACTION (2.329 Å) | 主引用文献 | Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus. J. Virol., 92, 2018
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6A0X
 
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7WCL
 
 | Crystal structure of FGFR1 kinase domain with Pemigatinib | 分子名称: | 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one, Fibroblast growth factor receptor 1, SULFATE ION | 著者 | Chen, X.J, Lin, Q.M, Jiang, L.Y, Qu, L.Z, Chen, Y.H. | 登録日 | 2021-12-20 | 公開日 | 2022-09-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.495 Å) | 主引用文献 | Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants. Commun Chem, 5, 2022
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7KXS
 
 | Computational design of constitutively active cGAS | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Dowling, Q, Volkman, H.E, Gray, E.E, Ovchinnikov, S, Cambier, S, Bera, A.K, Bick, M, Kang, A, Stetson, D.B, King, N.P. | 登録日 | 2020-12-04 | 公開日 | 2021-12-08 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Computational design of constitutively active cGAS. Nat.Struct.Mol.Biol., 30, 2023
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7LZ3
 
 | Computational design of constitutively active cGAS | 分子名称: | Cyclic GMP-AMP synthase, GLYCEROL, ZINC ION | 著者 | Dowling, Q, Volkman, H.E, Gray, E.E, Ovchinnikov, S, Cambier, S, Bera, A.K, Bick, M, Kang, A, Stetson, D.B, King, N.P. | 登録日 | 2021-03-08 | 公開日 | 2022-03-16 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Computational design of constitutively active cGAS. Nat.Struct.Mol.Biol., 30, 2023
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6TH6
 
 | Cryo-EM Structure of T. kodakarensis 70S ribosome | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | 登録日 | 2019-11-18 | 公開日 | 2020-07-29 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583, 2020
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7RAP
 
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8GVJ
 
 | Crystal structure of cMET kinase domain bound by D6808 | 分子名称: | (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor | 著者 | Chen, Y.H, Qu, L.Z. | 登録日 | 2022-09-15 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment. J.Med.Chem., 65, 2022
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8W5C
 
 | Crystal structure of FGFR4 kinase domain in complex with 8K | 分子名称: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide | 著者 | Zhang, Z.M, Huang, H.S. | 登録日 | 2023-08-26 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67, 2024
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3N2Y
 
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6E9X
 
 | DHF91 filament | 分子名称: | DHF91 filament | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | 登録日 | 2018-08-01 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | 主引用文献 | De novo design of self-assembling helical protein filaments. Science, 362, 2018
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9IVB
 
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6SKF
 
 | Cryo-EM Structure of T. kodakarensis 70S ribosome | 分子名称: | 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ... | 著者 | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | 登録日 | 2019-08-15 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583, 2020
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6SKG
 
 | Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M. | 登録日 | 2019-08-15 | 公開日 | 2020-07-29 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (2.65 Å) | 主引用文献 | Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping. Nature, 583, 2020
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5I7J
 
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5I7K
 
 | Crystal Structure of Human SPLUNC1 Dolphin Mutant D1 (G58A, S61A, G62E, G63D, G66D, I67T) | 分子名称: | BPI fold-containing family A member 1 | 著者 | Walton, W.G, Redinbo, M.R. | 登録日 | 2016-02-17 | 公開日 | 2016-05-18 | 最終更新日 | 2024-11-13 | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | 主引用文献 | Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1. Biochemistry, 55, 2016
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