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6DZP
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BU of 6dzp by Molmil
Cryo-EM Structure of Mycobacterium smegmatis C(minus) 50S ribosomal subunit
分子名称: 23S rRNA, 50S ribosomal protein L10, 50S ribosomal protein L11, ...
著者Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A.
登録日2018-07-05
公開日2018-10-03
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Zinc depletion induces ribosome hibernation in mycobacteria.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DZK
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BU of 6dzk by Molmil
Cryo-EM Structure of Mycobacterium smegmatis C(minus) 30S ribosomal subunit with MPY
分子名称: 16S rRNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
著者Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A.
登録日2018-07-05
公開日2018-09-19
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Zinc depletion induces ribosome hibernation in mycobacteria.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DZI
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BU of 6dzi by Molmil
Cryo-EM Structure of Mycobacterium smegmatis 70S C(minus) ribosome 70S-MPY complex
分子名称: 16S rRNA, 23 S rRNA (3119-MER), 30S ribosomal protein S10, ...
著者Sharma, M.R, Li, Y, Korripella, R, Yang, Y, Kaushal, P.S, Lin, Q, Wade, J.T, Gray, A.G, Derbyshire, K.M, Agrawal, R.K, Ojha, A.
登録日2018-07-05
公開日2018-09-26
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (3.46 Å)
主引用文献Zinc depletion induces ribosome hibernation in mycobacteria.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4G35
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BU of 4g35 by Molmil
Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.
分子名称: 4,4'-bis(bromomethyl)biphenyl, Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked)
著者Drake, E, Edwardraja, S, Lin, Q, Gulick, A.M.
登録日2012-07-13
公開日2012-12-05
最終更新日2024-11-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors.
J.Am.Chem.Soc., 134, 2012
2PY2
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BU of 2py2 by Molmil
Structure of Herring Type II Antifreeze Protein
分子名称: Antifreeze protein type II, CALCIUM ION
著者Liu, Y, Li, Z, Lin, Q, Seetharaman, J, Sivaraman, J, Hew, C.-L.
登録日2007-05-15
公開日2007-06-26
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structure and Evolutionary Origin of Ca-Dependent Herring Type II Antifreeze Protein.
PLoS ONE, 2, 2007
4R05
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BU of 4r05 by Molmil
Crystal structure of the refolded DENV3 methyltransferase
分子名称: Nonstructural protein NS5
著者Brecher, M.B, Li, Z, Zhang, J, Chen, H, Lin, Q, Liu, B, Li, H.M.
登録日2014-07-29
公開日2014-11-12
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase.
Protein Sci., 24, 2015
8Y2R
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BU of 8y2r by Molmil
NMR Solution Structure of the 2:1 Coptisine-ATF4-G4 Complex
分子名称: 6,7-dihydro[1,3]dioxolo[4,5-g][1,3]dioxolo[7,8]isoquino[3,2-a]isoquinolin-5-ium, DNA (5'-D(*TP*AP*AP*GP*GP*GP*AP*GP*GP*GP*AP*GP*GP*GP*AP*AP*GP*GP*GP*AP*GP*C*(LIG)*(LIG))-3')
著者Xiao, C.M, Li, Y.P, Liu, Y.S, Dong, R.F, He, X.Y, Lin, Q, Zang, X, Wang, K.B, Xia, Y.Z, Kong, L.Y.
登録日2024-01-27
公開日2024-12-04
最終更新日2025-06-18
実験手法SOLUTION NMR
主引用文献Overcoming Cancer Persister Cells by Stabilizing the ATF4 Promoter G-quadruplex.
Adv Sci, 11, 2024
8JMZ
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BU of 8jmz by Molmil
FGFR1 kinase domain with sulfatinib
分子名称: Fibroblast growth factor receptor 1, GLYCEROL, SULFATE ION, ...
著者Chen, X.J, Lin, Q.M, Chen, Y.H.
登録日2023-06-05
公開日2024-03-27
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.988 Å)
主引用文献Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Commun Chem, 7, 2024
8JOT
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BU of 8jot by Molmil
Crystal structure of CSF-1R kinase domain with sulfatinib
分子名称: GLYCEROL, Macrophage colony-stimulating factor 1 receptor, Sulfatinib
著者Lin, Q.M, Chen, X.J, Chen, Y.H.
登録日2023-06-08
公開日2024-03-27
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R.
Commun Chem, 7, 2024
6A0Z
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BU of 6a0z by Molmil
Crystal structure of broadly neutralizing antibody 13D4 bound to H5N1 influenza hemagglutinin, HA head region
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 13D4, Fab Heavy Chain, ...
著者Li, S, Li, T.
登録日2018-06-06
公開日2018-06-20
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.329 Å)
主引用文献Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus.
J. Virol., 92, 2018
6A0X
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BU of 6a0x by Molmil
Crystal structure of broadly neutralizing antibody 13D4
分子名称: Antibody 13D4, Fab Heavy Chain, Fab Light Chain
著者Li, S, Li, T.
登録日2018-06-06
公開日2018-06-20
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus.
J. Virol., 92, 2018
7WCL
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BU of 7wcl by Molmil
Crystal structure of FGFR1 kinase domain with Pemigatinib
分子名称: 11-[2,6-bis(fluoranyl)-3,5-dimethoxy-phenyl]-13-ethyl-4-(morpholin-4-ylmethyl)-5,7,11,13-tetrazatricyclo[7.4.0.0^{2,6}]trideca-1(9),2(6),3,7-tetraen-12-one, Fibroblast growth factor receptor 1, SULFATE ION
著者Chen, X.J, Lin, Q.M, Jiang, L.Y, Qu, L.Z, Chen, Y.H.
登録日2021-12-20
公開日2022-09-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.495 Å)
主引用文献Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants.
Commun Chem, 5, 2022
7KXS
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BU of 7kxs by Molmil
Computational design of constitutively active cGAS
分子名称: Cyclic GMP-AMP synthase, ZINC ION
著者Dowling, Q, Volkman, H.E, Gray, E.E, Ovchinnikov, S, Cambier, S, Bera, A.K, Bick, M, Kang, A, Stetson, D.B, King, N.P.
登録日2020-12-04
公開日2021-12-08
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Computational design of constitutively active cGAS.
Nat.Struct.Mol.Biol., 30, 2023
7LZ3
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BU of 7lz3 by Molmil
Computational design of constitutively active cGAS
分子名称: Cyclic GMP-AMP synthase, GLYCEROL, ZINC ION
著者Dowling, Q, Volkman, H.E, Gray, E.E, Ovchinnikov, S, Cambier, S, Bera, A.K, Bick, M, Kang, A, Stetson, D.B, King, N.P.
登録日2021-03-08
公開日2022-03-16
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.18 Å)
主引用文献Computational design of constitutively active cGAS.
Nat.Struct.Mol.Biol., 30, 2023
6TH6
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BU of 6th6 by Molmil
Cryo-EM Structure of T. kodakarensis 70S ribosome
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M.
登録日2019-11-18
公開日2020-07-29
最終更新日2024-04-24
実験手法ELECTRON MICROSCOPY (2.55 Å)
主引用文献Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Nature, 583, 2020
7RAP
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BU of 7rap by Molmil
Heterogeneous-backbone proteomimetic analogue of the disulfide-rich venom peptide lasiocepsin
分子名称: Heterogeneous-backbone analogue of lasiocepsin
著者Cabalteja, C.C, Horne, W.S.
登録日2021-07-02
公開日2022-05-04
最終更新日2023-11-15
実験手法SOLUTION NMR
主引用文献Heterogeneous-Backbone Proteomimetic Analogues of Lasiocepsin, a Disulfide-Rich Antimicrobial Peptide with a Compact Tertiary Fold.
Acs Chem.Biol., 17, 2022
8GVJ
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BU of 8gvj by Molmil
Crystal structure of cMET kinase domain bound by D6808
分子名称: (1^4Z,5^2E)-6^3-(trifluoromethyl)-5^1,5^6-dihydro-1^1H-8-aza-2(3,6)-quinolina-5(1,3)-pyridazina-1(4,1)-pyrazola-6(1,4)-benzenacyclododecaphane-5^6,7-dione, Hepatocyte growth factor receptor
著者Chen, Y.H, Qu, L.Z.
登録日2022-09-15
公開日2022-11-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
J.Med.Chem., 65, 2022
8W5C
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BU of 8w5c by Molmil
Crystal structure of FGFR4 kinase domain in complex with 8K
分子名称: Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-5-methanoyl-6-[(4-methylpiperazin-1-yl)methyl]-1-propan-2-yl-pyrrolo[3,2-b]pyridine-3-carboxamide
著者Zhang, Z.M, Huang, H.S.
登録日2023-08-26
公開日2024-07-31
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.
J.Med.Chem., 67, 2024
3N2Y
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BU of 3n2y by Molmil
Crystal structure of tyrosyl-tRNA synthetase complexed with p-(2-tetrazolyl)-phenylalanine
分子名称: 4-(2H-tetrazol-2-yl)-L-phenylalanine, Tyrosyl-tRNA synthetase
著者Wu, M, Li, J, Zang, J.
登録日2010-05-19
公開日2010-11-03
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献A biosynthetic route to photoclick chemistry on proteins
J.Am.Chem.Soc., 132, 2010
6E9X
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BU of 6e9x by Molmil
DHF91 filament
分子名称: DHF91 filament
著者Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D.
登録日2018-08-01
公開日2018-11-21
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (7.8 Å)
主引用文献De novo design of self-assembling helical protein filaments.
Science, 362, 2018
9IVB
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BU of 9ivb by Molmil
Crystal structure of c-Met kinase domain bound by bozitinib
分子名称: Hepatocyte growth factor receptor, bozitinib
著者Lin, H, Chen, Y.H.
登録日2024-07-23
公開日2025-01-22
最終更新日2025-02-12
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer.
Commun Biol, 8, 2025
6SKF
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BU of 6skf by Molmil
Cryo-EM Structure of T. kodakarensis 70S ribosome
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
著者Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M.
登録日2019-08-15
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Nature, 583, 2020
6SKG
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BU of 6skg by Molmil
Cryo-EM Structure of T. kodakarensis 70S ribosome in TkNat10 deleted strain
分子名称: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
著者Matzov, D, Sas-Chen, A, Thomas, J.M, Santangelo, T, Meier, J.L, Schwartz, S, Shalev-Benami, M.
登録日2019-08-15
公開日2020-07-29
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.65 Å)
主引用文献Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping.
Nature, 583, 2020
5I7J
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BU of 5i7j by Molmil
Crystal Structure of Human SPLUNC1 Disulfide Mutant M3 (I76C, V214C)
分子名称: BPI fold-containing family A member 1
著者Walton, W.G, Redinbo, M.R.
登録日2016-02-17
公開日2016-05-18
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.544 Å)
主引用文献Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.
Biochemistry, 55, 2016
5I7K
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Crystal Structure of Human SPLUNC1 Dolphin Mutant D1 (G58A, S61A, G62E, G63D, G66D, I67T)
分子名称: BPI fold-containing family A member 1
著者Walton, W.G, Redinbo, M.R.
登録日2016-02-17
公開日2016-05-18
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.552 Å)
主引用文献Structural Features Essential to the Antimicrobial Functions of Human SPLUNC1.
Biochemistry, 55, 2016

 

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