4G35
Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.
Summary for 4G35
| Entry DOI | 10.2210/pdb4g35/pdb |
| Related PRD ID | PRD_000921 |
| Descriptor | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog, Noxa BH3 peptide (cysteine-mediated cross-linked), 4,4'-bis(bromomethyl)biphenyl, ... (4 entities in total) |
| Functional Keywords | apoptosis, bh3 domain, bcl-2 family, apoptosis-inhibitor complex, apoptosis/inhibitor |
| Biological source | Mus musculus (mouse) More |
| Cellular location | Membrane; Single-pass membrane protein (By similarity): P97287 |
| Total number of polymer chains | 2 |
| Total formula weight | 21158.78 |
| Authors | Drake, E.,Edwardraja, S.,Lin, Q.,Gulick, A.M. (deposition date: 2012-07-13, release date: 2012-12-05, Last modification date: 2013-06-26) |
| Primary citation | Muppidi, A.,Doi, K.,Edwardraja, S.,Drake, E.J.,Gulick, A.M.,Wang, H.G.,Lin, Q. Rational design of proteolytically stable, cell-permeable peptide-based selective Mcl-1 inhibitors. J.Am.Chem.Soc., 134:14734-14737, 2012 Cited by PubMed: 22920569DOI: 10.1021/ja306864v PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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