4G35
Mcl-1 in complex with a biphenyl cross-linked Noxa peptide.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Induced myeloid leukemia cell differentiation protein Mcl-1 homolog | polymer | 165 | 18634.1 | 1 | UniProt (P97287) Pfam (PF00452) | Mus musculus (mouse) | Bcl-2-related protein EAT/mcl1 |
| 2 | B (B) | Noxa BH3 peptide (cysteine-mediated cross-linked) | polymer | 21 | 2184.7 | 1 | BIRD (PRD_000921) | ||
| 3 | C (B) | 4,4'-bis(bromomethyl)biphenyl | non-polymer | 340.1 | 1 | BIRD (PRD_000921) Chemie (4BP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 39 | Chemie (HOH) |
Sequence modifications
A: 171 - 327 (UniProt: P97287)
| PDB | External Database | Details |
|---|---|---|
| Gly 163 | - | expression tag |
| Pro 164 | - | expression tag |
| Leu 165 | - | expression tag |
| Gly 166 | - | expression tag |
| Ser 167 | - | expression tag |
| Pro 168 | - | expression tag |
| Glu 169 | - | expression tag |
| Phe 170 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20818.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 340.1 | |
| All* | Total formula weight | 21158.8 |
