7LZ3

Computational design of constitutively active cGAS

Summary for 7LZ3

Entry DOI	10.2210/pdb7lz3/pdb
Descriptor	Cyclic GMP-AMP synthase, ZINC ION, GLYCEROL, ... (4 entities in total)
Functional Keywords	de novo designed, constitutive mutant, cgas, de novo protein
Biological source	synthetic construct
Total number of polymer chains	2
Total formula weight	85235.30
Authors	Dowling, Q.,Volkman, H.E.,Gray, E.E.,Ovchinnikov, S.,Cambier, S.,Bera, A.K.,Bick, M.,Kang, A.,Stetson, D.B.,King, N.P. (deposition date: 2021-03-08, release date: 2022-03-16, Last modification date: 2023-02-01)
Primary citation	Dowling, Q.M.,Volkman, H.E.,Gray, E.E.,Ovchinnikov, S.,Cambier, S.,Bera, A.K.,Sankaran, B.,Johnson, M.R.,Bick, M.J.,Kang, A.,Stetson, D.B.,King, N.P. Computational design of constitutively active cGAS. Nat.Struct.Mol.Biol., 30:72-80, 2023 Cited by PubMed: 36593311 DOI: 10.1038/s41594-022-00862-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.18 Å)

Structure validation