7LZ3

Computational design of constitutively active cGAS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cyclic GMP-AMP synthase	polymer	362	42414.1	2		synthetic construct
2	C, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, E, G (A, B)	GLYCEROL	non-polymer		92.1	3	Chemie (GOL)
4	H, I (A, B)	water	water		18.0	207	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	84828.2
Non-Polymers*	Number of molecules	5
	Total formula weight	407.1
All*	Total formula weight	85235.3

*Water molecules are not included.