7DT8
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7DT3
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![BU of 7dt3 by Molmil](/molmil-images/mine/7dt3) | Crystal structure of human transthyretin in complex with 4-chloro-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid | 分子名称: | 4-chloranyl-9,10-bis(oxidanylidene)anthracene-2-carboxylic acid, CALCIUM ION, Transthyretin | 著者 | Kitakami, R, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-01-04 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.198 Å) | 主引用文献 | Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem., 44, 2021
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7DT5
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7DT6
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![BU of 7dt6 by Molmil](/molmil-images/mine/7dt6) | |
7EJQ
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![BU of 7ejq by Molmil](/molmil-images/mine/7ejq) | |
7EJR
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6AA4
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![BU of 6aa4 by Molmil](/molmil-images/mine/6aa4) | Crystal structure of MTH1 in complex with alpha-mangostin (cocktail No. 9) | 分子名称: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ... | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | 登録日 | 2018-07-17 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167, 2019
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6AA3
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![BU of 6aa3 by Molmil](/molmil-images/mine/6aa3) | Crystal structure of MTH1 in apo form (cocktail No. 1) | 分子名称: | 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ZINC ION | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | 登録日 | 2018-07-17 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167, 2019
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6AA5
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![BU of 6aa5 by Molmil](/molmil-images/mine/6aa5) | Crystal structure of MTH1 in complex with 3-isomangostin | 分子名称: | 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ... | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | 登録日 | 2018-07-17 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167, 2019
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6IMZ
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![BU of 6imz by Molmil](/molmil-images/mine/6imz) | Crystal structure of MTH1 in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ... | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
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6IN4
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![BU of 6in4 by Molmil](/molmil-images/mine/6in4) | Crystal structure of apo DAPK1 in the presence of 18-crown-6 | 分子名称: | Death-associated protein kinase 1, SULFATE ION | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
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6IN2
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![BU of 6in2 by Molmil](/molmil-images/mine/6in2) | Crystal structure of BRD1 in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ACETATE ION, Bromodomain-containing protein 1 | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
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6IN0
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![BU of 6in0 by Molmil](/molmil-images/mine/6in0) | Crystal structure of EphA3 in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, CHLORIDE ION, Ephrin type-A receptor 3 | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
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6IN3
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![BU of 6in3 by Molmil](/molmil-images/mine/6in3) | Crystal structure of DOT1L in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
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6IN1
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![BU of 6in1 by Molmil](/molmil-images/mine/6in1) | Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, ... | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-10-30 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitor To Be Published
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7W9Q
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![BU of 7w9q by Molmil](/molmil-images/mine/7w9q) | Crystal structure of V30M-TTR in complex with naringenin derivative-14 | 分子名称: | (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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7W9R
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![BU of 7w9r by Molmil](/molmil-images/mine/7w9r) | Crystal structure of V30M-TTR in complex with naringenin derivative-18 | 分子名称: | (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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6IMX
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![BU of 6imx by Molmil](/molmil-images/mine/6imx) | Crystal structure of V30M mutated transthyretin in complex with 18-Crown-6 | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62, 2019
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6IMY
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![BU of 6imy by Molmil](/molmil-images/mine/6imy) | Crystal structure of V30M mutated transthyretin in complex with 4'-caroboxybenzo-18-Crown-6 | 分子名称: | 2,3,5,6,8,9,11,12,14,15-decahydro-1,4,7,10,13,16-benzohexaoxacyclooctadecine-18-carboxylic acid, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Matsumoto, K, Kitakami, R, Nabeshima, Y, Mizuguchi, M. | 登録日 | 2018-10-24 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62, 2019
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