7DT8

Crystal structure of V30M mutated transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid

Summary for 7DT8

Entry DOI	10.2210/pdb7dt8/pdb
Descriptor	Transthyretin, CALCIUM ION, 4-chloranyl-9-oxidanylidene-xanthene-2-carboxylic acid, ... (4 entities in total)
Functional Keywords	inhibitor, complex, t4-binding, amyloidosis, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	35314.63
Authors	Kitakami, R.,Yokoyama, T.,Mizuguchi, M. (deposition date: 2021-01-04, release date: 2021-10-13, Last modification date: 2023-11-29)
Primary citation	Kitakami, R.,Inui, K.,Nakagawa, Y.,Sawai, Y.,Katayama, W.,Yokoyama, T.,Okada, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N.,Mizuguchi, M. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis. Bioorg.Med.Chem., 44:116292-116292, 2021 Cited by PubMed: 34225167 DOI: 10.1016/j.bmc.2021.116292 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.25 Å)

Structure validation