7DT8
Crystal structure of V30M mutated transthyretin in complex with 4-chloro-9-oxo-9H-xanthene-2-carboxylic acid
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Transthyretin | polymer | 159 | 17342.6 | 2 | UniProt (P02766) Pfam (PF00576) In PDB | Homo sapiens (Human) | ATTR,Prealbumin,TBPA |
2 | A, B | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
3 | A, B | 4-chloranyl-9-oxidanylidene-xanthene-2-carboxylic acid | non-polymer | 274.7 | 2 | Chemie (HH9) | |||
4 | water | water | 18.0 | 211 | Chemie (HOH) |
Sequence modifications
A, B: -19 - 127 (UniProt: P02766)
PDB | External Database | Details |
---|---|---|
Met -31 | - | initiating methionine |
Arg -30 | - | expression tag |
Gly -29 | - | expression tag |
Ser -28 | - | expression tag |
His -27 | - | expression tag |
His -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
Gly -21 | - | expression tag |
Ser -20 | - | expression tag |
Met 30 | Val 50 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 34685.2 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 629.5 | |
All* | Total formula weight | 35314.6 |