7W9R
Crystal structure of V30M-TTR in complex with naringenin derivative-18
Summary for 7W9R
| Entry DOI | 10.2210/pdb7w9r/pdb |
| Descriptor | Transthyretin, (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one (3 entities in total) |
| Functional Keywords | amyloidosis, complex, inhibitor, thyroxine, transport protein |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 2 |
| Total formula weight | 35367.45 |
| Authors | Katayama, W.,Shimane, A.,Nabeshima, Y.,Yokoyama, T.,Mizuguchi, M. (deposition date: 2021-12-10, release date: 2022-12-14, Last modification date: 2023-11-29) |
| Primary citation | Mizuguchi, M.,Nakagawa, Y.,Inui, K.,Katayama, W.,Sawai, Y.,Shimane, A.,Kitakami, R.,Okada, T.,Nabeshima, Y.,Yokoyama, T.,Kanamitsu, K.,Nakagawa, S.,Toyooka, N. Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65:16218-16233, 2022 Cited by PubMed: 36472374DOI: 10.1021/acs.jmedchem.2c00511 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.997 Å) |
Structure validation
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