6AA5
Crystal structure of MTH1 in complex with 3-isomangostin
Summary for 6AA5
| Entry DOI | 10.2210/pdb6aa5/pdb |
| Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, 5,9-dihydroxy-8-methoxy-2,2-dimethyl-7-(3-methylbut-2-en-1-yl)-3,4-dihydro-2H,6H-pyrano[3,2-b]xanthen-6-one, ZINC ION, ... (5 entities in total) |
| Functional Keywords | hydrolase, nudt1, antitumor protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 19688.31 |
| Authors | Yokoyama, T.,Kitakami, R.,Mizuguchi, M. (deposition date: 2018-07-17, release date: 2019-03-06, Last modification date: 2023-11-22) |
| Primary citation | Yokoyama, T.,Kitakami, R.,Mizuguchi, M. Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167:153-160, 2019 Cited by PubMed: 30771603DOI: 10.1016/j.ejmech.2019.02.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.901 Å) |
Structure validation
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