6IN1

Crystal structure of the first bromodomain of BRD4 in complex with 18-Crown-6

Summary for 6IN1

• Entry DOI: 10.2210/pdb6in1/pdb
• Descriptor: Bromodomain-containing protein 4, N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, ... (5 entities in total)
• Functional Keywords: bromodomain-containing protein 4, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 16847.30

Authors

Yokoyama, T.,Kosaka, Y.,Matsumoto, K.,Kitakami, R.,Nabeshima, Y.,Mizuguchi, M. (deposition date: 2018-10-24, release date: 2019-10-30, Last modification date: 2024-03-27)

• Primary citation: Yokoyama, T.,Kosaka, Y.,Matsumoto, K.,Kitakami, R.,Nabeshima, Y.,Mizuguchi, M.; Crown Ethers as Transthyretin Amyloidogenesis Inhibitor; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)