6IMX

Crystal structure of V30M mutated transthyretin in complex with 18-Crown-6

Summary for 6IMX

Entry DOI	10.2210/pdb6imx/pdb
Descriptor	Transthyretin, 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE (3 entities in total)
Functional Keywords	transthyretin, amyloid, t4-binding protein, transport protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	35213.79
Authors	Yokoyama, T.,Kosaka, Y.,Matsumoto, K.,Kitakami, R.,Nabeshima, Y.,Mizuguchi, M. (deposition date: 2018-10-24, release date: 2019-03-13, Last modification date: 2024-03-27)
Primary citation	Yokoyama, T.,Mizuguchi, M. Crown Ethers as Transthyretin Amyloidogenesis Inhibitors. J. Med. Chem., 62:2076-2082, 2019 Cited by PubMed: 30688456 DOI: 10.1021/acs.jmedchem.8b01700 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.602 Å)

Structure validation