6AA4
Crystal structure of MTH1 in complex with alpha-mangostin (cocktail No. 9)
Summary for 6AA4
| Entry DOI | 10.2210/pdb6aa4/pdb |
| Descriptor | 7,8-dihydro-8-oxoguanine triphosphatase, ZINC ION, 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, ... (5 entities in total) |
| Functional Keywords | hydrolase, nudt1, antitumor protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 19622.90 |
| Authors | Yokoyama, T.,Kitakami, R.,Mizuguchi, M. (deposition date: 2018-07-17, release date: 2019-03-06, Last modification date: 2023-11-22) |
| Primary citation | Yokoyama, T.,Kitakami, R.,Mizuguchi, M. Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167:153-160, 2019 Cited by PubMed: 30771603DOI: 10.1016/j.ejmech.2019.02.011 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
Download full validation report
