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3ZC7
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BU of 3zc7 by Molmil
VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin and ATP
分子名称: ADENOSINE MONOPHOSPHATE-PROTEIN TRANSFERASE VBHT, ADENOSINE-5'-TRIPHOSPHATE, ANTITOXIN VBHA
著者Goepfert, A, Schirmer, T.
登録日2012-11-19
公開日2013-06-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold.
Plos One, 8, 2013
3ZCB
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BU of 3zcb by Molmil
VbhT Fic protein from Bartonella schoenbuchensis in complex with VbhA antitoxin mutant E24G and ATP
分子名称: ADENOSINE MONOPHOSPHATE-PROTEIN TRANSFERASE VBHT, ADENOSINE-5'-TRIPHOSPHATE, ANTITOXIN VBHA, ...
著者Goepfert, A, Schirmer, T.
登録日2012-11-19
公開日2013-06-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold.
Plos One, 8, 2013
3ZCN
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BU of 3zcn by Molmil
Fic protein from SHEWANELLA ONEIDENSIS in complex with ATP
分子名称: ADENOSINE MONOPHOSPHATE-PROTEIN TRANSFERASE SOFIC, ADENOSINE-5'-TRIPHOSPHATE
著者Goepfert, A, Schirmer, T.
登録日2012-11-21
公開日2013-06-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold.
Plos One, 8, 2013
3ZLM
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BU of 3zlm by Molmil
Fic protein from Neisseria meningitidis mutant E186G in complex with AMPPNP
分子名称: ADENOSINE MONOPHOSPHATE-PROTEIN TRANSFERASE NMFIC, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Goepfert, A, Schirmer, T.
登録日2013-02-01
公開日2013-06-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold.
Plos One, 8, 2013
3ZEC
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BU of 3zec by Molmil
Fic protein from SHEWANELLA ONEIDENSIS (E73G mutant) in complex with AMPPNP
分子名称: ADENOSINE MONOPHOSPHATE-PROTEIN TRANSFERASE SOFIC, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Goepfert, A, Schirmer, T.
登録日2012-12-04
公開日2013-06-19
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold.
Plos One, 8, 2013
7ZAN
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BU of 7zan by Molmil
Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, Interleukin-17A, ...
著者Rondeau, J.M, Goepfert, A.
登録日2022-03-22
公開日2022-10-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (5.061 Å)
主引用文献IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Cell Rep, 41, 2022
3SHG
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BU of 3shg by Molmil
VBHT Fic protein from BARTONELLA SCHOENBUCHENSIS in complex with VBHA antitoxin
分子名称: L(+)-TARTARIC ACID, VbhA, VbhT
著者Goepfert, A, Schirmer, T.
登録日2011-06-16
公開日2012-01-25
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.
Nature, 482, 2012
3SE5
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BU of 3se5 by Molmil
Fic protein from NEISSERIA MENINGITIDIS mutant delta8 in complex with AMPPNP
分子名称: Cell filamentation protein Fic-related protein, HEXAETHYLENE GLYCOL, MAGNESIUM ION, ...
著者Goepfert, A, Stanger, F, Schirmer, T.
登録日2011-06-10
公開日2012-01-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.
Nature, 482, 2012
3SN9
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BU of 3sn9 by Molmil
Fic protein from NEISSERIA MENINGITIDIS mutant S182A/E186A in complex with AMPPNP
分子名称: Cell filamentation protein Fic-related protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Goepfert, A, Stanger, F, Schirmer, T.
登録日2011-06-29
公開日2012-01-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.
Nature, 482, 2012
5EU0
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BU of 5eu0 by Molmil
FIC domain of Bep1 from Bartonella rochalimae in complex with BiaA
分子名称: Bartonella effector protein (Bep) substrate of VirB T4SS, SULFATE ION, antitoxin 1
著者Goepfert, A.
登録日2015-11-18
公開日2017-03-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular basis for Rho-family GTPase discrimination by a bacterial virulence factor
to be published
5N9B
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BU of 5n9b by Molmil
Crystal Structure of unliganded human IL-17RA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A
著者Rondeau, J.-M, Goepfert, A.
登録日2017-02-24
公開日2018-06-13
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献IL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Cell Rep, 41, 2022
5N92
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BU of 5n92 by Molmil
Crystal Structure of Human IL-17AF
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17A, Interleukin-17F
著者Rondeau, J.-M, Goepfert, A.
登録日2017-02-24
公開日2017-09-06
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.
Sci Rep, 7, 2017
5NAN
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BU of 5nan by Molmil
Crystal Structure of human IL-17AF in complex with human IL-17RA
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-D-galactopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor A, ...
著者Rondeau, J.-M, Goepfert, A.
登録日2017-02-28
公開日2017-09-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The human IL-17A/F heterodimer: a two-faced cytokine with unique receptor recognition properties.
Sci Rep, 7, 2017
6HG4
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BU of 6hg4 by Molmil
Crystal Structure of the human IL-17RC ECD in complex with human IL-17F
分子名称: Interleukin-17 receptor C, Interleukin-17F
著者Rondeau, J.M, Goepfert, A.
登録日2018-08-22
公開日2020-03-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.32 Å)
主引用文献Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
6HGU
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BU of 6hgu by Molmil
Crystal Structure of an anti-APP-tag Fab
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GLYCEROL, anti-APP-tag Fab heavy-chain, ...
著者Rondeau, J.M, Goepfert, A.
登録日2018-08-23
公開日2019-11-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
6HG9
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BU of 6hg9 by Molmil
Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II
分子名称: Interleukin-17 receptor C, Interleukin-17F
著者Rondeau, J.M, Goepfert, A.
登録日2018-08-23
公開日2020-03-18
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.62 Å)
主引用文献Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
6HGA
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BU of 6hga by Molmil
Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17 receptor C, anti-APP-tag Fab heavy-chain, ...
著者Rondeau, J.M, Goepfert, A.
登録日2018-08-23
公開日2020-03-18
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
6HGO
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BU of 6hgo by Molmil
Crystal Structure of human IL-17F
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-17F, ...
著者Rondeau, J.M, Goepfert, A.
登録日2018-08-23
公開日2019-11-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.
Immunity, 52, 2020
5EW3
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BU of 5ew3 by Molmil
Human Vascular Endothelial Growth Factor Receptor 2 (KDR) Kinase Domain in complex with AAL993
分子名称: 2-(pyridin-4-ylmethylamino)-~{N}-[3-(trifluoromethyl)phenyl]benzamide, Vascular endothelial growth factor receptor 2
著者Stark, W, Goepfert, A.
登録日2015-11-20
公開日2015-12-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献A Novel Potent Oral Series of VEGFR2 Inhibitors Abrogate Tumor Growth by Inhibiting Angiogenesis.
J.Med.Chem., 59, 2016
3S6A
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BU of 3s6a by Molmil
Fic protein from NEISSERIA MENINGITIDIS in complex with AMPPNP
分子名称: Cell filamentation protein Fic-related protein, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Stanger, F, Goepfert, A, Schirmer, T.
登録日2011-05-25
公開日2012-01-25
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Adenylylation control by intra- or intermolecular active-site obstruction in Fic proteins.
Nature, 482, 2012
6YJM
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BU of 6yjm by Molmil
Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with the Inhibitor GLPG1972
分子名称: (5~{S})-5-[3-[(3~{S})-4-[3,5-bis(fluoranyl)phenyl]-3-methyl-piperazin-1-yl]-3-oxidanylidene-propyl]-5-cyclopropyl-imidazolidine-2,4-dione, A disintegrin and metalloproteinase with thrombospondin motifs 5, CALCIUM ION, ...
著者Goepfert, A, Leonard, P, Triballeau, N, Fleury, D, Mollat, P, Lamers, M.
登録日2020-04-03
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis.
J.Med.Chem., 64, 2021
3FEA
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BU of 3fea by Molmil
Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2 at 1.33A
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2
著者Kallen, J.
登録日2008-11-28
公開日2009-01-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
3FE7
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Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2 at 1.35A
分子名称: Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2
著者Kallen, J.
登録日2008-11-28
公開日2009-01-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
J.Biol.Chem., 284, 2009
2JK8
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BU of 2jk8 by Molmil
Type IV secretion system effector protein BepA complexed with a pyrophosphate moiety
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Palanivelu, D.V, Schirmer, T.
登録日2008-08-22
公開日2009-11-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Fic Domain Catalyzed Adenylylation: Insight Provided by the Structural Analysis of the Type Iv Secretion System Effector Bepa.
Protein Sci., 20, 2011
2VY3
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BU of 2vy3 by Molmil
Type IV secretion system effector protein BepA
分子名称: CELL FILAMENTATION PROTEIN, CHLORIDE ION, NICKEL (II) ION
著者Palanivelu, D.V, Schirmer, T.
登録日2008-07-17
公開日2009-11-17
最終更新日2011-11-09
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Fic Domain Catalyzed Adenylylation: Insight Provided by the Structural Analysis of the Type Iv Secretion System Effector Bepa.
Protein Sci., 20, 2011

 

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