3FE7

Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2 at 1.35A

Summary for 3FE7

• Entry DOI: 10.2210/pdb3fe7/pdb
• Related: 3DAB 3FEA
• Descriptor: Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-Trp-Glu-Ac3c-Leu-NH2 (3 entities in total)
• Functional Keywords: hdmx, hdm4, human mdm4, human mdmx, protein-protein interaction, p53, cell cycle, alternative splicing, metal-binding, nucleus, polymorphism, zinc, zinc-finger
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus: O15151
• Total number of polymer chains: 2
• Total formula weight: 12345.27

Authors

Kallen, J. (deposition date: 2008-11-28, release date: 2009-01-27, Last modification date: 2023-11-22)

• Primary citation: Kallen, J.,Goepfert, A.,Blechschmidt, A.,Izaac, A.,Geiser, M.,Tavares, G.,Ramage, P.,Furet, P.,Masuya, K.,Lisztwan, J.; Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes; J.Biol.Chem., 284:8812-8821, 2009; PubMed: 19153082; DOI: 10.1074/jbc.M809096200

Experimental method

X-RAY DIFFRACTION (1.35 Å)