6YJM

Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with the Inhibitor GLPG1972

Summary for 6YJM

Entry DOI	10.2210/pdb6yjm/pdb
Descriptor	A disintegrin and metalloproteinase with thrombospondin motifs 5, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywords	zinc metalloproteinase, aggrecanase, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	50586.08
Authors	Goepfert, A.,Leonard, P.,Triballeau, N.,Fleury, D.,Mollat, P.,Lamers, M. (deposition date: 2020-04-03, release date: 2021-04-14, Last modification date: 2024-01-24)
Primary citation	Brebion, F.,Gosmini, R.,Deprez, P.,Varin, M.,Peixoto, C.,Alvey, L.,Jary, H.,Bienvenu, N.,Triballeau, N.,Blanque, R.,Cottereaux, C.,Christophe, T.,Vandervoort, N.,Mollat, P.,Touitou, R.,Leonard, P.,De Ceuninck, F.,Botez, I.,Monjardet, A.,van der Aar, E.,Amantini, D. Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS-5 Inhibitor for the Treatment of Osteoarthritis. J.Med.Chem., 64:2937-2952, 2021 Cited by PubMed: 33719441 DOI: 10.1021/acs.jmedchem.0c02008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation