6YJM
Crystal Structure of the Catalytic Domain of ADAMTS-5 in Complex with the Inhibitor GLPG1972
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | HIS410 |
| A | HIS414 |
| A | HIS420 |
| A | OU5505 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | CA503 |
| A | HOH608 |
| A | GLU270 |
| A | ASP353 |
| A | ASP360 |
| A | CYS471 |
| A | ASP474 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 503 |
| Chain | Residue |
| A | GLU270 |
| A | ASP353 |
| A | ASP474 |
| A | CA502 |
| A | HOH610 |
| A | HOH612 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 504 |
| Chain | Residue |
| A | ASP369 |
| A | LEU370 |
| A | CYS376 |
| A | THR378 |
| A | GLU398 |
| A | HOH639 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue OU5 A 505 |
| Chain | Residue |
| A | THR378 |
| A | LEU379 |
| A | GLY380 |
| A | MET381 |
| A | HIS403 |
| A | PHE406 |
| A | THR407 |
| A | HIS410 |
| A | GLU411 |
| A | HIS414 |
| A | HIS420 |
| A | ARG437 |
| A | LEU438 |
| A | SER440 |
| A | SER441 |
| A | THR444 |
| A | ILE446 |
| A | ZN501 |
| A | HOH619 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | HIS410 |
| B | HIS414 |
| B | HIS420 |
| B | OU5505 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 502 |
| Chain | Residue |
| B | GLU270 |
| B | ASP353 |
| B | ASP360 |
| B | CYS471 |
| B | ASP474 |
| B | CA503 |
| B | HOH605 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 503 |
| Chain | Residue |
| B | GLU270 |
| B | ASP353 |
| B | ASP474 |
| B | CA502 |
| B | HOH607 |
| B | HOH614 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 504 |
| Chain | Residue |
| B | ASP369 |
| B | LEU370 |
| B | CYS376 |
| B | THR378 |
| B | GLU398 |
| B | HOH630 |
| site_id | AD1 |
| Number of Residues | 18 |
| Details | binding site for residue OU5 B 505 |
| Chain | Residue |
| B | THR378 |
| B | LEU379 |
| B | GLY380 |
| B | HIS403 |
| B | PHE406 |
| B | HIS410 |
| B | GLU411 |
| B | HIS420 |
| B | ARG437 |
| B | LEU438 |
| B | SER440 |
| B | SER441 |
| B | LEU443 |
| B | THR444 |
| B | ILE446 |
| B | ZN501 |
| B | HOH603 |
| B | HOH623 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHEIGHLL |
| Chain | Residue | Details |
| A | THR407-LEU416 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18042673","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
