6HG4

Crystal Structure of the human IL-17RC ECD in complex with human IL-17F

Summary for 6HG4

• Entry DOI: 10.2210/pdb6hg4/pdb
• Descriptor: Interleukin-17F, Interleukin-17 receptor C (2 entities in total)
• Functional Keywords: cystine-knot, fniii domains, receptor-cytokine complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 66150.21

Authors

Rondeau, J.M.,Goepfert, A. (deposition date: 2018-08-22, release date: 2020-03-18, Last modification date: 2024-01-17)

• Primary citation: Goepfert, A.,Lehmann, S.,Blank, J.,Kolbinger, F.,Rondeau, J.M.; Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.; Immunity, 52:499-512.e5, 2020; PubMed: 32187518; DOI: 10.1016/j.immuni.2020.02.004

Experimental method

X-RAY DIFFRACTION (3.32 Å)