6HG4

Crystal Structure of the human IL-17RC ECD in complex with human IL-17F

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Interleukin-17F	polymer	139	15695.9	1	UniProt (Q96PD4) Pfam (PF06083)	Homo sapiens (Human)	IL-17F,Cytokine ML-1
2	B (B)	Interleukin-17 receptor C	polymer	451	50454.3	1	UniProt (Q8NAC3) Pfam (PF15037)	Homo sapiens (Human)	IL-17RC,Interleukin-17 receptor homolog,IL17Rhom,Interleukin-17 receptor-like protein,IL-17RL,ZcytoR14

Sequence modifications

A: 31 - 163 (UniProt: Q96PD4)

PDB	External Database	Details
Glu 25	-	expression tag
Phe 26	-	expression tag
Arg 27	-	expression tag
His 28	-	expression tag
Asp 29	-	expression tag
Ser 30	-	expression tag

B: 21 - 467 (UniProt: Q8NAC3)

PDB	External Database	Details
Gln 186	Asn 186	engineered mutation
Gln 226	Asn 226	engineered mutation
Gln 253	Asn 253	engineered mutation
Gln 263	Asn 263	engineered mutation
Arg 307	Gln 307	engineered mutation
Gln 349	Asn 349	engineered mutation
Gln 372	Asn 372	engineered mutation
Gln 406	Asn 406	engineered mutation
Glu 468	-	expression tag
Phe 469	-	expression tag
Arg 470	-	expression tag
His 471	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66150.2
All*	Total formula weight	66150.2

*Water molecules are not included.