3FEA

Crystal Structure of HdmX bound to the p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2 at 1.33A

Summary for 3FEA

Entry DOI	10.2210/pdb3fea/pdb
Related	3DAB 3FE7
Descriptor	Mdm4 protein, p53-peptidomimetic Ac-Phe-Met-Aib-Pmp-6-Cl-Trp-Glu-Ac3c-Leu-NH2, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (4 entities in total)
Functional Keywords	hdmx, hdm4, human mdm4, human mdmx, protein-protein interaction, p53, metal-binding, nucleus, polymorphism, zinc, zinc-finger, cell cycle
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: O15151
Total number of polymer chains	3
Total formula weight	13690.62
Authors	Kallen, J. (deposition date: 2008-11-28, release date: 2009-01-27, Last modification date: 2023-11-22)
Primary citation	Kallen, J.,Goepfert, A.,Blechschmidt, A.,Izaac, A.,Geiser, M.,Tavares, G.,Ramage, P.,Furet, P.,Masuya, K.,Lisztwan, J. Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes J.Biol.Chem., 284:8812-8821, 2009 Cited by PubMed: 19153082 DOI: 10.1074/jbc.M809096200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.33 Å)

Structure validation