6HGA

Crystal Structure of the human IL-17RC D2-D3-D4 domains in complex with an anti-APP tag Fab

Summary for 6HGA

• Entry DOI: 10.2210/pdb6hga/pdb
• Related: 6HG4 6HG9
• Descriptor: Interleukin-17 receptor C, anti-APP-tag Fab heavy-chain, anti-APP-tag Fab light-chain, ... (5 entities in total)
• Functional Keywords: fniii domains, fab complex, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 77996.71

Authors

Rondeau, J.M.,Goepfert, A. (deposition date: 2018-08-23, release date: 2020-03-18, Last modification date: 2020-07-29)

• Primary citation: Goepfert, A.,Lehmann, S.,Blank, J.,Kolbinger, F.,Rondeau, J.M.; Structural Analysis Reveals that the Cytokine IL-17F Forms a Homodimeric Complex with Receptor IL-17RC to Drive IL-17RA-Independent Signaling.; Immunity, 52:499-512.e5, 2020; PubMed: 32187518; DOI: 10.1016/j.immuni.2020.02.004

Experimental method

X-RAY DIFFRACTION (2.6 Å)